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Two Onc Docs

Sam and Karine·197 episodes

HealthFitnessMedicine

This is Sam and Karine, and we are Two Onc Docs! We both graduated from our Heme/Onc fellowships in 2021 and became board certified in both Hematology and Oncology. Our mission with Two Onc Docs is to create short board review episodes that you can listen to on your drive to work, while you make your morning coffee, or between pages on call. This is intended to be a supplement to other established board studying resources for busy trainees. *This podcast is intended to be an educational resource for health care providers.*

Episodes

11 min
May 25, 2026Episode 6
ASCO Annual Meeting 2026 Preview

Today we will be focusing on exciting data to come at the ASCO Annual Meeting in 2026 in Chicago, with a special focus on GU sessions, educational sessions & med ed sessions.

13 min
May 18, 2026Episode 5
Von Willebrand Disease (VWD) 2026 UPDATE

This week’s episode will be focusing on Von Willebrand disease (VWD), a highly testable bleeding disorder. We will go over all the important details on the diagnosis, types of VWD as well as treatment.

11 min
May 11, 2026Episode 4
Aplastic Anemia 2026 UPDATE

Today’s episode is focusing on the highest yield facts about Aplastic Anemia. This will include the mechanism of AA, diagnostic work-up, treatment of AA, and the evolution of clones including PNH.

9 min
May 4, 2026Episode 3
Metastatic Bladder Cancer 2026 UPDATE

Today’s episode is focusing on what you need to know regarding metastatic bladder cancer, with 2026 updates. This will include the need to know treatment options and toxicities for metastatic urothelial carcinoma, and also discuss the management of upper tract + variant non-urothelial histology.

13 min
Apr 27, 2026Episode 2
Localized Bladder Cancer 2026 UPDATE

Today’s episode is focusing on what you need to know regarding localized bladder cancer, with 2026 updates. This will include the need to know pathology, presentation, diagnostic work-up, staging, and treatment options.

12 min
Apr 20, 2026Episode 1
4 Years with Two Onc Docs

This week’s episode will be focusing on how we met, the future of the podcast, and why we picked heme/onc. This is a very different style of episode and a special once because this month is our 4 year anniversary of Two Onc Docs! And we will back to our regular programming next week with overdue updates on Bladder Cancer.

14 min
Apr 13, 2026
Pancreatic Cancer x Dr. Michael Pishvaian 2026 UPDATE Part 3

We are back with a very special guest Dr. Michael Pishvaian, who is an Associate Professor in GI Oncology at the Johns Hopkins Kimmel Cancer Center, and creator of Tumor Board Tuesday. In part 3, we discuss supportive care in pancreatic cancer, and exciting trials in this space.

25 min
Apr 6, 2026
Metastatic Pancreatic Cancer x Dr. Michael Pishvaian 2026 UPDATE Part 2

We are back with a very special guest Dr. Michael Pishvaian, who is an Associate Professor in GI Oncology at the Johns Hopkins Kimmel Cancer Center, and creator of Tumor Board Tuesday. In part 2, we will focus on metastatic pancreatic cancer, 1L treatments, maintenance therapy, targeted therapy + more.

37 min
Mar 30, 2026
Localized Pancreatic Cancer x Dr. Michael Pishvaian 2026 UPDATE Part 1

This week’s episode will be discussing Pancreatic Cancer with a very special guest Dr. Michael Pishvaian. Dr. Pishvaian is an Associate Professor in GI Oncology at the Johns Hopkins Kimmel Cancer Center, and creator of Tumor Board Tuesday. In part 1, we will focus on risk factors, diagnosis and treatment of localized pancreatic cancer.

12 min
Mar 23, 2026
ASCO GU 2026 Takeaways

This week’s episode will be focusing on a recap of some of the important data ASCO GU just held in San Francisco end of February. We will go over some topics in prostate, RCC, bladder cancer, and other GU tumors.

23 min
Mar 16, 2026
Neuroendocrine Tumors 2026 UPDATE

This week’s episode will be focusing on Neuroendocrine Tumors (NET). We will go over all the important details regarding the heterogeneous group of NETs, diagnosis, work-up, treatment, and focus mostly on gastro-entero-pancreatic NETs.

14 min
Mar 9, 2026
Venous Thromboembolism (VTE) in Cancer Part 2

This week’s episode we are back with our special guest & thrombosis expert Dr. Marc Carrier.  In part 2, we discuss additional special considerations like IVC filter indications, and management of VTEs in the setting of thrombocytopenia. We also discuss VTE prevention in patients with cancer, the Khorana score, exciting research to come in this space, and career advice.

12 min
Mar 2, 2026
Venous Thromboembolism (VTE) in Cancer Part 1

This week’s episode will be focusing on a very important topic, with our special guest Dr. Marc Carrier. Dr. Carrier is a Professor in the Faculty of Medicine, and holds a Tier 1 Clinical Research Chair in Venous Thromboembolism and Cancer from the Faculty of Medicine at the University of Ottawa. We discuss the work-up and treatment of VTEs and cancer, including types of anti-coagulation, duration, and special considerations.

11 min
Feb 24, 2026Episode 7
ASCO GU 2026 Preview

This week’s episode we discuss what to look forward to at ASCO GU this week. Held in SF Feb 26-28 in San Francisco. We will go over the program in prostate cancer, kidney cancer, bladder cancer, as well as testicular cancer.

16 min
Feb 16, 2026Episode 6
Rad Onc 101 Part 2

This week’s episode, we are back with our special guest Dr. Ria Kraft, a radiation oncologist and host of Rad Onc Talks. In part 2, we go over important details on duration + fractionation schemes, indications for palliative RT, other indications for RT in metastatic disease, and more.

18 min
Feb 9, 2026
Rad Onc 101 Part 1

This week’s episode will be focusing on basics of radiation oncology. We are so excited to welcome a special guest Dr. Ria Kraft, who has a YouTube channel called Rad Onc Talks for radiation oncology education. In part 1, we go over important details on types of radiation, how it works, the patient experience, common side effects and more.

34 min
Feb 3, 2026Episode 5
Career Pathways in Heme/Onc with Special Guest Dr. Chadi Nabhan

This week’s episode we are so excited to welcome Dr. Chadi Nabhan, who is a hematologist and medical oncologist, author, and host of Healthcare Unfiltered. We discuss why oncology, our career paths, different career paths in hematology and oncology, contract & negotiation considerations, as well as tips to search for a job.

15 min
Jan 19, 2026Episode 3
Oncology Nutrition 101 Part 2

This week’s episode is a new topic! We will be focusing on basics of nutrition in oncology. We are so excited to welcome a very special guest Dr. Krystle Zuniga, who is a board-certified specialist in oncology nutrition. In part 2, we will go over dietary strategies focusing on cancer prevention, and myths around what causes cancer.

26 min
Jan 12, 2026Episode 2
Oncology Nutrition 101 Part 1

This week’s episode is a new topic! We will be focusing on basics of nutrition in oncology. We are so excited to welcome a very special guest Dr. Krystle Zuniga, who is a board-certified specialist in oncology nutrition. In part 1, we will go over information + myths in oncology nutrition including cancer feeds sugar, fiber, estrogen, supplements, fasting, and more.

13 min
Jan 5, 2026Episode 1
Follicular Lymphoma 2026 UPDATE

Happy New Year! This week’s episode will be focusing on 2026 update for Follicular Lymphoma. We will go over the important details on the diagnostic criteria, indications for treatment and types + toxicities of treatment.

11 min
Dec 16, 2025Episode 32
ASH 2025 LBA BRUIN-CLL 313 Update: Pirtobrutinib vs Bendamustine/Rituximab in 1L CLL

This week’s episode will be focusing on an update of a late-breaking abstract presented at ASH 2025 this past week: the Phase 3 BRUIN-CLL 313 trial looking at Pirtobrutinib vs Bendamustine/Rituximab in 1L Chronic Lymphocytic Leukemia (CLL).

17 min
Dec 8, 2025Episode 31
Gastrointestinal Stromal Tumor (GIST) 2025 UPDATE

This week’s episode will be focusing on gastrointestinal stromal tumors, known as GIST with a 2025 update. We will go over important details on the diagnosis, mutations, and treatment of local and metastatic GISTs.

17 min
Nov 24, 2025Episode 30
Hodgkin Lymphoma 2025 UPDATE

This week’s episode is also due for an update since it aired in 2022. Will be focusing on Hodgkin Lymphoma (HL), both classical and nodular lymphocyte-predominant. We will go into important details on the pathology, staging, Deauville scoring, and treatment for early stage/advanced stage as well as relapsed and refractory HL.

11 min
Nov 17, 2025Episode 29
Anal Cancer 2025 UPDATE

Today’s episode is focusing on what you need to know regarding Anal cancer. This was one of our first episodes back in 2022 so it is time for an updated episode! This will include the important details on risk factors, diagnostic work-up, staging and treatment of both localized and metastatic anal cancer.

13 min
Nov 10, 2025Episode 28
Urothelial ESMO 2025 Updates

This week’s episode will be on many exciting updates were announced at ESMO this October in Berlin from Oct 17-21, 2025, especially in bladder cancer, we continue to make such progress! We discuss key trials in NMIBC (POTOMAC), MIBC (KN-905, IMvigor-011), and metastatic urothelial carcinoma (FORAGER-1, DV + Toripalimab).

16 min
Nov 3, 2025Episode 27
Board Review Tidbits

This week’s episode will be focusing on details of the hematology & oncology board exams, how we prepared the days leading up to our exam, and we cover some highly tested topics in both hematology & oncology. We wish the best of luck to everyone taking their boards this year!

9 min
Oct 27, 2025Episode 27
Porphyria

This week’s episode will be focusing on Porphyrias…which is very timely since this week is HALLOWEEN and porphyrias are the diseases many people believe started the vampire legend!

11 min
Oct 20, 2025Episode 26
Metastatic Breast Cancer 2025 UPDATE

This week’s episode is part 3 of our breast cancer series, with a 2025 update focusing on metastatic breast cancer systemic therapies, toxicities, and supportive care considerations.

17 min
Oct 13, 2025Episode 25
Localized Breast Cancer 2025 UPDATE

This week’s episode will be focusing on treatment options for localized breast cancer with 2025 updates. We will go over important details on indications for adjuvant radiation, as well as therapies based on the ER/PR/HER-2 receptor status.

17 min
Oct 6, 2025Episode 24
Breast Cancer Screening, Prevention & Intro 2025 UPDATE

October marks Breast Cancer Awareness Month. We are providing 2025 update for our 3 part breast cancer episodes, in part 1 today we cover an introduction on breast cancer screening, prevention.

14 min
Sep 29, 2025Episode 24
Esophageal and Gastrosophageal Junction (GEJ) Cancer 2025 UPDATE

This week’s episode will be focusing on Esophageal and Gastrosophageal Junction (GEJ) Cancer. We will go over important details on the risk factors, diagnosis, and treatment for both localized and metastatic esophageal cancer.

9 min
Sep 22, 2025Episode 23
Immune Thrombocytopenia Purpura ( ITP) 2025 UPDATE

This week’s episode will be focusing on Immune Thrombocytopenia Purpura ( ITP).   We will go all the important details on causes, mechanism, diagnosis and treatment. The last time we covered this topic was in Sept 2022, and this comes up ALL the time in heme consults, and there will definitely be board review questions. It may also be tested on IM boards.

13 min
Sep 15, 2025Episode 22
Bone Sarcomas 2025 UPDATE

This week’s episode will be an update on Bone Sarcomas. We will go over the important details on diagnosis, staging, subtypes and treatment of a few bone sarcomas. Just like Soft Tissue Sarcomas, these are RARE tumors encompassing 1% of all adult cancers and having multiple subtypes. They are more common in children, and most of our bone sarcoma recommendations that are testable are based on pediatric data.

21 min
Sep 9, 2025Episode 21
Soft Tissue Sarcomas 2025 UPDATE

This week’s episode will be focusing on soft tissue sarcomas. We last recorded this topic in 2023, and well we have some new FDA approvals and updates since then.We will go over the important details on the diagnosis, subtypes and treatment of a few soft tissue sarcomas. These are RARE tumors encompassing 1% of all adult cancers and having multiple subtypes that range from noncancerous tumors such as desmoid tumors to aggressive cancers and everything in between.

10 min
Aug 26, 2025Episode 20
Thrombotic Thrombocytopenic Purpura (TTP) and other TMAs 2025 UPDATE

Today’s episode will focus on an update for commonly tested Thrombotic microangiopathies (TMA) such as Thrombotic Thrombocytopenic Purpura (TTP). This will include the high yield facts on mechanism, presentation, diagnostic work-up, and treatment of TTP, and also discuss Hemolytic Uremic Syndrome (HUS), and atypical HUS.

18 min
Aug 19, 2025Episode 19
Gastric Cancer 2025 UPDATE

This week’s episode will be focusing on Gastric Adenocarcinoma. We will go over all the important details on risk factors, diagnostic work-up, staging and treatment for both local regional disease and metastatic disease with updates in 2025 since we last covered this topic in 2023.

12 min
Aug 11, 2025Episode 18
Endometrial (Uterine) Cancer 2025 UPDATE

We are updating another important GYN ONC topic: endometrial (uterine) cancer. We will go over all the important details on the risk factors, presentation, diagnosis, staging & treatment options. We will also cover rare uterine malignancies at the end of the episode.

30 min
Aug 4, 2025Episode 19
Metastatic Kidney Cancer x Uromigos 2025 UPDATES (Part 2)

Today’s episode we will cover 2025 updates for metastatic renal cell carcinoma. We will discuss risk categories, treatment options, and variant histologies. We are so excited to have Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos sharing their expertise on today's episode as well!

20 min
Jul 28, 2025Episode 18
Localized Kidney Cancer x Uromigos 2025 UPDATES (Part 1)

Today’s episode we will cover 2025 updates for localized renal cell carcinoma (RCC) with Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos! We will discuss risk factors, the presentation, staging, and treatment options.

11 min
Jul 21, 2025Episode 17
Cervical Cancer 2025 UPDATE

This week’s episode will be focusing on Cervical Cancer with some updates since we last released this topic in 2022. We will go over important details on prevention, risk factors, diagnosis & treatment.

12 min
Jul 15, 2025Episode 17
Oncologic Emergencies 2025 Update

This week’s episode is an update on a must-know topics both for new fellows & residents. We will go over clinically important oncologic emergencies including brain metastases, hypercalcemia of malignancy, cord compression and SVC syndrome.

12 min
Jul 7, 2025Episode 16
ASCO 2025 Plenary - MATTERHORN

This week’s episode will be focusing on one of the GI plenary session abstracts presented at the ASCO Annual Meeting 2025,  the MATTERHORN trial: phase 3 durvalumab + FLOT which is 5FU leucovorin, oxaliplatin and docetaxel in resectable gastric or GE junction CA.

15 min
Jun 30, 2025Episode 16
Preparing for Fellowship 101

This week’s episode will be focusing on how to prepare for the start of heme/onc fellowship! We will go over some general advice on how to succeed, study tips and resources we used throughout fellowship as well as some tips on how to stay academically productive during training if you are planning for an academic career.

12 min
Jun 24, 2025Episode 15
ASCO 2025 Plenary: SERENA-6

This week’s episode will be focusing on one of the 2025 plenary sessions: SERENA-6, Camizestrant, a novel selective estrogen receptor degrader (SERD) + CDK 4/6i for tx of emergent ESR1 during 1L endocrine-based therapy + ahead of progression in stage 4 HR+/Her-2 negative breast cancer.We discuss the trial design, endpoints, results, safety concerns, and how it fits into current practice.

12 min
Jun 16, 2025Episode 14
Ovarian Cancer 2025 UPDATE

This week’s episode will be focusing on Ovarian Cancer with 2025 updates since we last covered this topic in 2022. We will go over all important details on the risk factors, presentation, diagnosis, staging & treatment options for both localized and metastatic disease.

12 min
Jun 9, 2025Episode 14
ASCO Annual Meeting 2025 GU Updates

This week’s episode will be focusing on exciting data in GU presented at the 2025 ASCO Annual Meeting in prostate (including prognostication of PSA response in mCSPC, AMPLITUDE - PARPi in mCSPC), RCC (including updates in KN-564, CM-214 and PDIGREE), and finally bladder CA (with updates in NIAGARA and EV-302) among others.

11 min
May 27, 2025Episode 13
ASCO 2025 Preview

This week’s episode will be focusing on exciting data to come at the ASCO Annual Meeting 2025 starting with the plenary sessions, then a special focus on the GU abstracts, including prostate CA, renal cell carcinoma, bladder CA, and a quick shout-out for some of the medical education sessions.

15 min
May 12, 2025Episode 12
Hepatocellular Carcinoma (HCC) 2025 UPDATE

This week’s episode will be focusing on hepatocellular carcinoma (HCC). We will go over important details on assessing liver function, staging of HCC and loco-regional as well as systemic treatment options for HCC.

29 min
May 5, 2025Episode 11
Stem Cell Transplant (SCT) Part 2 x Dr. Jeff Auletta 2025 UPDATE

This week’s episode will be focusing on Hematopoietic Stem Cell Transplant. We welcome our guest  Dr. Jeff Auletta, Senior Vice President, National Marrow Donor Program, and Chief Scientific Director,Center for International Blood and Marrow Transplant Research. Part 2 discusses conditioning regimens, graft-vs-host disease, toxicities, and Dr. Auletta's career path.

26 min
Apr 28, 2025Episode 10
Stem Cell Transplant (SCT) Part 1 x Dr. Jeff Auletta 2025 UPDATE

This week’s episode will be focusing on Hematopoietic Stem Cell Transplant. We welcome our guest  Dr. Jeff Auletta, Senior Vice President, National Marrow Donor Program, and Chief Scientific Director,Center for International Blood and Marrow Transplant Research. Part 1 discusses important basics including what a transplant is, types of transplant & associated risks, types of donors, how to find a donor, and barriers/inequities of finding a donor.

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