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The Long Run with Luke Timmerman artwork

The Long Run with Luke Timmerman

Timmerman Report·200 episodes

Science

"The Long Run" Antarctic explorer Ernest Shackleton would appreciate today's biotech. Scientific entrepreneurs of the 21st century must be ready for what Shackleton called the “hazardous journey, bitter cold, long months of complete darkness, constant danger, safe return doubtful, honor and recognition in case of success.” Today, the men and women who strive to apply science for the betterment of human health have a historic opportunity. They need stamina and resilience to achieve something meaningful. Biotech’s relationship with the society that sustains it has never been more tenuous. Join host Luke Timmerman for in-depth, thought-provoking conversations with biotech newsmakers pursui...

Episodes

1 hr 8 min
Jun 2, 2026Episode 202
Becky Pferdehirt on Reimagining Science for the AI Era

Becky Pferdehirt, CEO of Emeryville, CA-based Radial, the life sciences unit of Astera Institute, on reimagining biology to take advantage of advances in AI.

1 hr 8 min
May 19, 2026Episode 201
Jeremy Levin on Biotech in the Balance

Jeremy Levin, executive chair of Ovid Therapeutics, discusses his new book "Biotech in the Balance: Saving a Strategic Industry in an Age of Distrust."

1 hr 13 min
May 5, 2026Episode 200
Richard Pops Reflects on a 35-Year Career in Biotech

Alkermes CEO Richard Pops reflects on his 35-year career leading the company and its new opportunity in orexin biology for sleep disorders and more neurological conditions.

1 hr 10 min
Apr 21, 2026Episode 199
Martin Burke on Making Small Molecule Medicines for the AI Era

Marty Burke, a professor of chemistry at the University of Illinois and co-founder of Excelsior Sciences, on making small molecule synthesis more automated for AI.

1 hr 16 min
Apr 7, 2026Episode 198
Abbas Kazimi on Computation and Culture for Drug Discovery

Abbas Kazimi, CEO of Boston-based Nimbus Therapeutics, on computation and culture for drug discovery.

1 hr 16 min
Mar 31, 2026Episode 197
Viswa Colluru on Discovering Drugs Inspired by Mother Nature

Viswa Colluru, founder and CEO of Boulder, Colo.-based Enveda, on drug discovery with a chemistry platform inspired by natural products.

1 hr 3 min
Mar 17, 2026Episode 196
Otello Stampacchia on Europe's Biotech Crisis

Otello Stampacchia, founder and managing director of Omega Funds, on attempting to reform Europe's biotech investment climate.

1 hr 5 min
Mar 3, 2026Episode 195
Ken Song on T-cell Engagers for Autoimmune Diseases

Ken Song, CEO of San Diego-based Candid Therapeutics, on developing bispecific T-cell engaging antibodies for autoimmune disease.

1 hr 8 min
Feb 17, 2026Episode 194
Ansu Satpathy on Cancer and Autoimmune Drug Discovery

Ep194: Ansu Satpathy on Cancer and Autoimmune Drug Discovery by Timmerman Report

1 hr 5 min
Jan 22, 2026Episode 193
Ron Renaud on Helping People Lose Weight With GLP-1 Medicines

Ron Renaud, CEO of Waltham, Mass.-based Kailera Therapeutics, on developing GLP-1 based medicines to help people lose weight and live healthier lives.

1 hr 26 min
Jan 8, 2026Episode 192
Kate Haviland on Following the Science to Precision Immunology

Kate Haviland, former CEO of Blueprint Medicines, on how the company transitioned to a precision immunology company and was acquired by Sanofi for $9.5 billion.

1 hr 7 min
Dec 15, 2025Episode 191
Emily Conley on Small Molecules to Correct a Rare Kidney Disease

Emily Conley, CEO of Berkeley, CA-based Renasant Bio, on developing small molecule correctors and potentiators for autosomal dominant polycystic kidney disease (ADPKD).

1 hr 13 min
Nov 20, 2025Episode 190
Neil Kumar on Building a Rare Disease Drug Company

Neil Kumar is founder and CEO of Palo Alto, Calif.-based BridgeBio Pharma, a rare disease drug developer.

1 hr 12 min
Nov 12, 2025Episode 189
Marc Tessier-Lavigne on Reinventing Drug Discovery with AI

Marc Tessier-Lavigne, CEO of South San Francisco-based Xaira Therapeutics, on reinventing drug discovery with AI.

1 hr 9 min
Oct 28, 2025Episode 188
Art Krieg on Innate Immune System Activators for Cancer

Art Krieg, founder and CEO of Zola Therapeutics, on developing innate immune system activators for cancer.

1 hr 5 min
Oct 14, 2025Episode 187
Eric Fischer on Creating a New Class of Medicines

Eric Fischer, a professor at Dana-Farber Cancer Institute, on creating a new class medicines -- targeted protein degraders.

1 hr 2 min
Sep 29, 2025Episode 186
Bruce Levine & Mags McCarthy on a Song About Science and Hope

Bruce Levine, a CAR-T cell therapy researcher at the University of Pennsylvania, and Mags McCarthy, a country music star, discuss their new song about science and hope for cancer patients.

1 hr 5 min
Sep 17, 2025Episode 185
Dr. Lachelle Weeks on Predicting Leukemia Risk At Scale

Dr. Lachelle Weeks is a physician-scientist at Dana-Farber Cancer Institute working on a project to predict leukemia risk based on widely available blood samples.

1 hr 50 min
Aug 28, 2025Episode 184
Jen Adair on Affordable, Accessible Gene & Cell Therapies

Jen Adair, professor and associate director of the Horae Gene Therapy Center at the University of Massachusetts Chan Medical School, on creating more affordable and accessible cell and gene therapies.

56 min
Aug 6, 2025Episode 183
Sabah Oney on CAR-T Cells Against Solid Tumors

Sabah Oney, CEO of Philadelphia and San Francisco-based Dispatch Biotherapeutics, on engineering CAR-T cells that can kill solid tumors.

1 hr 1 min
Jul 23, 2025Episode 182
Andy Rachleff & Yung Lie on Creative Ways to Back Science

Andy Rachleff and Yung Lie, board chair and CEO of Damon Runyon Cancer Research Foundation, on creative ways to support science amid budget cuts.

57 min
Jul 1, 2025Episode 181
Claire Mazumdar on a Two-Pronged Attack Against Cancer

Claire Mazumdar, CEO of Boston-based Bicara Therapeutics, on developing a bifunctional antibody for head and neck cancer.

1 hr 10 min
Jun 11, 2025Episode 180
John Rinn on Discovering Drugs Based on Long Non-Coding RNA

John Rinn, professor at the University of Colorado and co-founder of Lincswitch Therapeutics, on exploring long non-coding RNA.

1 hr 3 min
May 28, 2025Episode 179
Ethan Weiss & Josh Lehrer on a New Idea for Cardiovascular Disease & Diabetes

Marea Therapeutics CEO Josh Lehrer and CSO Ethan Weiss on a new angle of attack against cardiovascular disease and diabetes.

1 hr 2 min
May 13, 2025Episode 178
Peyton Greenside on ML-Guided Biologics Discovery

Peyton Greenside, co-founder and CEO of BigHat Biosciences, on machine-learning guided biologic drug discovery.

58 min
Apr 14, 2025Episode 177
Kevin Parker on Finding Cancer Drug Targets

Kevin Parker, CEO of Cartography Biosciences, on finding new cancer drug targets.

1 hr 19 min
Mar 31, 2025Episode 176
David Roblin on Building a TechBio Company

David Roblin, CEO of London-based Relation Therapeutics, on building a techbio discovery company.

1 hr 10 min
Mar 16, 2025Episode 175
Andy Scharenberg on in vivo CAR-T cell therapies

Andy Scharenberg, CEO of Seattle-based Umoja Biopharma, on developing in vivo CAR-T cell therapies.

1 hr 7 min
Mar 3, 2025Episode 174
Najat Khan on the TechBio Movement

Najat Khan, chief R&D and chief commercial officer of Recursion, on using technology to improve drug discovery.

57 min
Feb 11, 2025Episode 173
Robert Blum on Building a Fully Integrated Biopharma For Muscle Disorders

Robert Blum, CEO of South San Francisco-based Cytokinetics, on building a fully integrated biopharma to treat muscle disorders.

1 hr 20 min
Jan 27, 2025Episode 172
Mostafa Ronaghi on Studying Live Cells at Scale

Mostafa Ronaghi, co-founder and executive board member of Cellanome, on developing technology to look at live cells and cellular interactions at scale.

1 hr 1 min
Jan 13, 2025Episode 171
Ram Aiyar on RNA Editing Medicines

Ram Aiyar, CEO of Cambridge, Mass.-based Korro Bio, on RNA editing medicines.

59 min
Jan 2, 2025Episode 170
David Schenkein on Investing in the Future of Biotech

David Schenkein, general partner at GV, on investing in the future of biotech.

1 hr 2 min
Dec 11, 2024Episode 169
Kevin Fitzgerald on the Past & Future of RNAi Medicines

Alnylam Pharmaceuticals chief scientific officer Kevin Fitzgerald on the past, present & future of RNA interference medicines.

1 hr
Nov 25, 2024Episode 168
Jonathan Bricker on How to Quit Smoking & Prevent Cancer

Jonathan Bricker, professor in the cancer prevention program at Fred Hutchinson Cancer Center, on how to quit smoking with help from tech and biotech tools.

1 hr 11 min
Nov 6, 2024Episode 167
Leslie Williams on transfer RNA therapies

Leslie Williams, CEO of Boston-based hC Bioscience, on developing transfer RNA therapies.

1 hr 3 min
Oct 15, 2024Episode 166
Chris Garcia on Engineering Protein Drugs for Cancer, Autoimmunity

Chris Garcia, professor at Stanford University and co-founder of several biotech startups, on using protein engineering to advance new treatments for cancer and autoimmune diseases.

1 hr 2 min
Sep 26, 2024Episode 165
Zach Hornby on Tackling Cancer Drug Resistance

Zach Hornby, CEO of San Diego-based Boundless Bio, on tackling cancer drug resistance.

56 min
Sep 5, 2024Episode 164
Ted Love and Alan Anderson on Raising the Bar for Sickle Cell Disease Patients

Ted Love, chairman of BIO, and Dr. Alan Anderson, executive director of Sickle Forward, on how to improve quality of life for sickle cell disease patients around the world.

1 hr 8 min
Aug 14, 2024Episode 163
Sarah Boyce on RNA Medicines for Muscle Diseases

Sarah Boyce, CEO of San Diego-based Avidity Biosciences, on RNA medicines for rare muscle diseases.

1 hr 5 min
Jul 16, 2024Episode 162
Sean McClain on AI for Biologic Drug Discovery

Sean McClain, CEO of Absci, on using AI to speed up biologic drug discovery.

1 hr 8 min
Jul 1, 2024Episode 161
Jeff Stein on a Long-Lasting Flu Drug

Jeff Stein, CEO of San Diego-based Cidara Therapeutics, on a long-lasting drug against flu.

1 hr 8 min
Jun 17, 2024Episode 160
Abe Ceesay on Precision Neuroscience

Abe Ceesay, CEO of Boston-based Rapport Therapeutics, on a precision medicine approach to neuroscience drug discovery.

1 hr 7 min
Jun 3, 2024Episode 159
Jimi Olaghere on Being Functionally Cured of Sickle Cell Disease

Jimi Olaghere is one of the first patients to have been functionally cured of sickle cell disease with a CRISPR gene-edited cell therapy.

1 hr
May 20, 2024Episode 158
David Younger and Randolph Lopez on SynBio & AI for Discovery

David Younger and Randolph Lopez, co-founders of A-Alpha Bio, on using synthetic biology and AI to discover new biologic drugs.

56 min
May 1, 2024Episode 157
Vineeta Agarwala of A16Z on Investing in AI for Drug Discovery

Vineeta Agarwala, general partner at A16Z's Bio & Health fund, on investing in AI for drug discovery.

1 hr 52 min
Apr 16, 2024Episode 156
David Liu on New Tools and Techniques for Biology

David Liu, professor of chemistry at Harvard University and co-founder of multiple biotech companies, including Beam Therapeutics and Prime Medicine.

1 hr 2 min
Mar 6, 2024Episode 155
Valerie Daggett on Early Detection, and Treatment, of Alzheimer's

Valerie Daggett, founder and CEO of Seattle-based AltPep, on early detection and treatment of Alzheimer's.

1 hr 3 min
Feb 9, 2024Episode 154
Robert Ang on CRISPR to Protect Bone Marrow & Attack Cancer

Robert Ang, CEO of Cambridge, Mass.-based Vor Bio, on using CRISPR gene editing to alter bone marrow transplants and improve treatment of acute myeloid leukemia.

1 hr 1 min
Jan 22, 2024Episode 153
Rick Young on Studying Gene Expression for Drug Discovery

Rick Young, professor at MIT and co-founder of Syros Pharmaceuticals, CAMP4 Therapeutics, Omega Therapeutics, and Dewpoint Therapeutics, on studying gene expression for drug discovery.

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