The Human Upgrade: Biohacking for Longevity & Performance

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to.  Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event  Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel’s products at: getwonderfeel.com/dave Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.   Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic infla

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol  If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner.  Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch.  This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear.  You'll Learn: Why everyone who is chronically sick has a low cortisol awakening response and what to do about it How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both The parasite epidemic in the U.S. and why standard testing misses most of it How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID Why synthetic B

In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating to 80% full shuts down the constant growth signaling that accelerates cellular aging. We'll also cover why the modern concept of retirement physically destroys your brain function within 2-3 years, and how specific social structures actually drop inflammatory chemicals in your body by up to 30%.Thank you to our sponsors!TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:47 – Okinawa's Origins01:28 – Hara Hachibu (80% Full)02:36 – Ikigai (Purpose)03:57 – Never Retire05:19 – Social Bonds (Moai)07:13 – Stress Resilience08:54 – The 5 HabitsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Light Therapy, 40Hz Gamma & Brainwave Entrainment: How BrainTap Resets Sleep, Clears Brain Fog, and Boosts Productivity by 26% Your brain is being starved of the one nutrient it needs most, and it is not a supplement, not a nootropic, not a fasting protocol. It is light, and a 40 hertz flicker delivered at the right frequency can break up amyloid plaque, reset your nervous system, and get you 26 percent more productive in a single session.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners  Host Dave Asprey sits down with Dr. Patrick Porter, PhD, award-winning author, educator, entrepreneur, and founder of BrainTap, who has spent over 35 years at the forefront of neurotechnology helping millions of people achieve mental and emotional resilience through cutting-edge brain entrainment tools. Backed by 72 peer-reviewed studies and research conducted alongside Google, Microsoft, universities in Brazil, and veteran treatment programs, Dr. Porter is one of the most experienced and validated practitioners in applied neuroscience and brain optimization working today.  Together, Dave and Dr. Porter break down exactly how flickering light and binaural sound delivered through the BrainTap headset feeds the brain through the electron transport chain, triggers nitric oxide release, boosts mitochondrial energy, and drives neuroplasticity through frequency following response. They cover how 40 hertz gamma light breaks up amyloid plaque and why that same frequency is linked to reversing dementia, how BrainTap reset the circadian rhythms of coal miners in under three weeks, how 490,000 students in Brazil raised their GPA using brain wave entrainment, and how AI now builds personalized 21-day brain training protocols from 3,000 available sessions. If you are serious about biohacking your brain, upgrading sleep optimization, and doing smarter not harder work on your mind, this episode delivers the science and the tools.  You'll Learn: Why light is the most underrated nutrient for brain health and how BrainTap delivers it directly to every cell in your body How 40 hertz gamma frequency breaks up amyloid plaque, restores blood flow, and may reverse dementia and Alzheimer's progression Why binaural beats and isochronic tones trigger frequency following response and what that does to your focus, metabolism, and energy How three 10-minute BrainTap sessions per day produces 26 percent more work output according to studies with Google and Microsoft How BrainTap restored deep sleep and REM

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeline.com/Dave or just use code ‘Dave’ to get 20% off your next order.  Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show.  Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up.  You'll Learn: Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks Why D

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity.  Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenerget

Most guys over 40 rely on coffee just to survive the day, completely unaware that they are pushing their brains into a frantic, high-stress state that actually destroys deep focus and accelerates cognitive decline. In this video, I reveal the science behind why caffeine is failing you and introduce you to a 4,000-year-old amino acid used by monks to achieve effortless, sustained attention. I'll walk you through the optimal 2:1 biohacking stack that flips your coffee from a nervous, jittery habit into a highly controlled focus weapon. You'll learn exactly how to dose it, when to take it, and how to stop the hidden lifestyle habits that are secretly sabotaging your nervous system, so you can reclaim the mental edge you had in your twenties and stay competitive.Thank you to our sponsors!-HeartMath | Go to https://www.heartmath.com/dave to save 15% off-The One Device | Use code DAVE for $10 off at theonedevice.com/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:21 – Background & Credentials01:28 – How Caffeine Works03:01 – Alpha vs Beta Brainwaves04:06 – The Focus Amino Acid04:55 – What Is L-Theanine05:35 – Quality & Common Mistakes06:51 – Building the Stack08:37 – Lifestyle Foundations10:36 – Rules & GuidelinesConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave Asprey breaks down why sleep deprivation is just another form of brain energy stress, how creatine's phosphate-buffering mechanism stabilizes ATP in the prefrontal cortex under pressure, and why this changes how he thinks about red-eye flights and all-nighters. Vegetarians and women showed the largest effects ... your baseline diet sets your ceiling. Sources: https://pubmed.ncbi.nlm.nih.gov/42075005/ https://www.nutraingredients.com/Article/2026/04/21/single-dose-creatine-may-support-cognition-in-sleep-deprivation-study/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/ https://medicalxpress.com/news/2024-04-creatine-cognitive-deprivation.html   Your Gum Is Dosing You With Thousands of Microplastics A pilot study tested 10 commercial gums ... five synthetic, five marketed as natural or plastic-free ... and found every single one shed hundreds to roughly 3,000 microplastic fragments per stick into saliva, with no meaningful difference between synthetic and "natural" varieties. Host Dave Asprey connects this to total toxic load management, explains why "natural" label claims mean nothing without polymer-free verification, and makes the case that even innocent daily habits contribute to the cumulative plastic burden most people aren't tracking. The takeaway isn't panic ... it's precision. Sources: https://www.acs.org/pressroom/presspacs/2025/march/chewing-gum-can-shed-microplastics-into-saliva-pilot-study-finds.html https://www.sciencedirect.com/science/article/pii/S2666911025000243 <a href="https://samueli.ucla.edu/bursting-your-bubble-chewing-gum-releases-microplastics-into-your-sal

If you're over 50 and still doing cardio to stay healthy, you're wasting your time and may actually be making things worse. This episode breaks down the exact movements, supplements, and anti-aging strategies that build real strength, protect your bones, and extend your longevity without spending hours in the gym.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Will Harlow, a master's-level physiotherapist and founder of HT Physio, whose YouTube channel has amassed over 1.5 million subscribers by teaching people over 50 how to stay mobile, active, and independent without painkillers or surgery. Will graduated with a first-class degree from Brunel University, trained in both the NHS and professional sport, and has spent his career proving that what most doctors call "just aging" is actually optional.  Together, Dave and Will dismantle the myths keeping older adults weak, injured, and overtrained. They get into why resistance training beats cardio for human performance and metabolism at every age, how anabolic resistance changes your protein needs after 50, which three compound movements deliver the biggest functional gains, and why your grip strength may be the most underrated biomarker you're ignoring. Dave also shares how he used biohacking, targeted supplements, and functional medicine principles to grow bones so dense his surgeon couldn't cut through them. They also dig into vestibular training, hydration, magnesium, Vitamin DAKE, and how tools like AI are now helping people identify movement problems before they become joint replacements.  This is essential listening for anyone serious about longevity, anti-aging, biohacking, sleep optimization, supplements, smarter not harder training, human performance, and building a body that performs decades past its expiration date.  You'll Learn: Why chronic cardio decreases bone density and muscle mass in people over 50 The 3-2-1 resistance training method that delivers 80% of results in 40 minutes a week How anabolic resistance changes protein requirements as you age and what to do about it The three compound movements every person over 50 should master first Why grip strength predicts overall health and how to train it How vestibular disorders silently destroy balance and confidence, and how to reverse them The supplement stack (Vitamin DAKE, magnesium glycinate, digestive enzymes) that supports bone, muscle, and metabolism Why 7,000 steps beats 10,000, and where that number actually came from How Dave used biohacking and functional medicine to grow bones that broke a surgeon's saw Why AI tools can now sp

The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR John Gray wrote Men Are from Mars, Women Are from Venus, the number one bestselling book of the entire decade and one of USA Today's top 10 most influential books of the last quarter century. His books have been translated into 45 languages across more than 100 countries. But what most people miss is that Gray is also a pioneer in the intersection of hormonal health, brain optimization, and human performance, a biohacker before the word existed. His newest book, Men Are from Mars for Women Only: Be Happy With or Without a Man, is the first in a six-part series packed with cutting-edge insights on relationships, biology, and longevity. Host Dave Asprey and John Gray go deep on the hormonal mechanics of desire, attraction, and emotional regulation, covering why societal testosterone collapse is driving relationship breakdown, how estrogen and testosterone function as a polarity system in both men and women, and why the relational environment you create every day is either building or destroying your biological potential. They also cover lithium orotate as a brain optimization supplement, the anti-aging power of semen retention, pre-digested protein as a nootropics-adjacent tool for brain healing, and how fasting and discipline directly boost testosterone. Gray even shares how he reversed early-stage Parkinson's using biohacking techniques and now maintains a testosterone level of 600 at age 74, with zero pharmaceutical support. This is essential listening for anyone serious about biohacking, longevity, anti-aging, supplements, human performance, brain optimization, functional medicine, metabolism, and hacking the biology of love and attraction. You'll Learn: Why testosterone collapse is the hidden driver behind modern relationship failure How your partner's emotional state directly affects your hormones in real time The prolactin trap that kills sexual desire in long-term relationships and how to escape it Why lithium orotate is one of the most underrated supplements for dopamine and serotonin balance How mirror neurons open and close based on stress, and what that means for emotional connection The five-finger ask technique that raises estrogen and testosterone simultaneously How pre-digesting protein with enzymes achieves 93 percent assimilation and supports brain repai

If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD).I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm.Thank you to our sponsors!-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air-The One Device | Use code DAVE for $10 off at theonedevice.com/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:40 – Gut Ecosystem01:00 – Constant Snacking02:57 – Gut-Brain Connection03:40 – Why Standard Fasting Can Backfire07:22 – The Fasting Sweet Spot09:21 – Introducing the FMD10:43 – Pre-Reset: Prep Days13:24 – The 5-Day FMD Protocol16:47 – Meal Timing & Circadian Rhythm17:46 – Sleep, Stress & Recovery18:22 – How Often to Do FMD19:23 – WrapupConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at <a href="https://art19.c

*Testosterone Directly Suppresses Brain Tumor Growth in Males by 38% Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells — the root of tumor recurrence — and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation therapy may be doing to every other cancer pathway simultaneously, and why your hormone panel is now a cancer conversation, not just a performance one. Sources:  -https://www.nih.gov/news-events/news-releases/nih-funded-study-suggests-testosterone-suppresses-brain-tumor-growth-males  -https://bioengineer.org/nih-funded-research-indicates-testosterone-may-inhibit-brain-tumor-growth-in-males/  *CDC Halts Rabies Testing Nationwide  A CDC staffing crisis has pushed rabies, mpox, and Epstein-Barr testing to overwhelmed state labs, creating one-to-two week diagnostic delays in a disease where post-exposure prophylaxis must begin within ten days of a bite — and where fatality is virtually 100% once symptoms appear. Dave explains exactly what to do if you or a pet is exposed, why outdoor biohackers are the most exposed population, and what pre-travel prevention looks like for anyone heading to endemic regions. Sources:  -https://www.nbcnews.com/health/health-news/cdc-pauses-testing-rabies-monkeypox-epstein-barr-viruses-rcna266377  -https://www.cidrap.umn.edu/rabies/state-public-health-labs-step-cdc-pauses-testing-various-pathogens-including-rabies-mpox  *Mifepristone Mail Ban  The Supreme Court issued a one-week stay blocking a 5th Circuit ruling that would have ended telehealth and mail access to mifepristone, used in over 63% of U.S. abortions. Dave sets aside the moral debate to focus on what this legal precedent means for FDA-approved compounded peptides, bioidentical hormones, and telehealth access to any treatment without full pharmaceutical backing — and why this case is one every biohacker should be tracking closely. Sources:  -<a href="https://www.usnews.com/news/health-news/articles/2026-05-05/supreme-court-issues-stay-keeping-abortion-pill-mifepristone-available-by-ma

What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philippe Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling frontiers in biohacking today: quantum energy fields delivered remotely, in real time, to your body, your pets, your home, and even your business.  -Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Philippe Samor von Holtzendorff-Fehling is a coach, conscious entrepreneur, and energy healer who built a parallel path alongside a high-level international business career, working through his own blockages to fully connect with his true self. He served as Vice President at both T-Mobile International and T-Mobile US, and is now the founder and CEO of Leela Quantum Tech and Quantum Upgrade. He is also a kundalini yoga teacher, a passionate bio and bio-energy hacker, a father of two, a dog lover, and the number one ranked tennis player in the US in the Men 50+ category. His work sits at the intersection of functional medicine, quantum biology, and human performance, and the science behind his technology is harder to dismiss than most people expect. Dave and Philippe go deep on how chronic EMF exposure from 5G towers, Starlink satellites, electric vehicles, and everyday Wi-Fi actively disrupts your brain waves, blood cells, heart rate variability, and mitochondria function. They also break down how Quantum Upgrade works as a remote, customizable field that can harmonize these frequencies in real time, and why it may be one of the most underrated tools for sleep optimization, brain optimization, recovery, anti-aging, and longevity. This episode also covers the groundbreaking work Philippe is doing with autistic children, including a clinical study showing measurable reductions in autism spectrum scores, and a remarkable collaboration with Susie Miller of the Telepathy Tapes. This is essential listening for anyone serious about biohacking, human performance, anti-aging, longevity, brain optimization, sleep optimization, functional medicine, mitochondria health, and hacking every system in your body with smarter not harder solutions. You'll Learn: Why EMF from 5G, Starlink, and electric vehicles is more biologically dangerous than most people realize How a 256-channel EEG captured real-time brain changes triggered by Quantum Upgr

Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in Aging (2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today. Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought. This is essential listening for anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using smarter not harder strategies to take control of your biology. You'll Learn: How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow Why the Horvath epigenetic clock may actually be touching on programmatic aging rather than just exposomic wear and tear How AI is unlocking patterns in longevity data that no human researcher could find alone The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's lo

I spent fifteen years living with brain fog until I realized the problem wasn’t in my brain, but in a nervous system stuck in a survival mode that pulls energy away from focus and memory. In this video, I explain why "trying harder" or popping supplements rarely works, and instead, I show you the 9,000-year-old ritual of heat and cold that pulls your body out of stress mode so clarity can actually return. I break down the specific science of how I use infrared wavelengths and contrast therapy to retrain the brain to stay calm under pressure, moving beyond temporary fixes to target the root cause of mental fatigue. Follow this protocol to finally complete your body's stress cycles, reset your biological default settings, and reclaim the lasting mental performance you’ve been missing.00:00 – Introduction01:02 – What Brain Fog Really Is03:00 – Why Trying Harder Doesn't Work04:51 – Supplements: Useful But Not Enough06:14 – Why Sauna Works07:32 – Infrared vs Traditional Sauna08:02 – Sunlighten Sauna Overview09:28 – Sauna Routine & Protocol10:34 – Why Home Access Matters11:41 – Post-Session Recovery12:11 – Contrast Therapy13:11 – How to Do Contrast Therapy13:54 – Closing & TakeawaysThank you to our sponsors!-TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.-Neuronic | Go to www.neuronic.online Code DAVE for $100 off-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVEConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at <a href="https://art19.com/privacy

This week's stories: *Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30% Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune system requires microbial exposure to calibrate properly, what the hygiene hypothesis actually means for adults, and the dead-simple weekly habit that primes your innate immunity the same way. Sources: https://creators.yahoo.com/lifestyle/story/finland-replaced-artificial-playground-surfaces-with-natural-elements-like-mud-and-soil--and-the-results-surprised-even-researchers-184318556.html https://www.sciencedaily.com/releases/2026/04/mud-playground-immunity.htm *Mixing Exercise Types Cuts All-Cause Mortality Up to 40% in 170,000-Person Study A 30-year BMJ Medicine cohort study found that people who rotate at least three different types of exercise weekly see 19 to 40% lower all-cause mortality — and that benefit held independent of total training volume. Dave explains why variety is a distinct biological signal, not a motivation trick, and why grinding more of the same thing is leaving longevity gains on the table. Sources: https://bmjmedicine.bmj.com/content/early/2026/04/26/bmjmed-2025-001513 https://www.sciencedaily.com/releases/2026/04/260426012305.htm https://www.theguardian.com/society/2026/apr/26/exercise-diversity-mortality *Facial Aging Rate from Photos Predicts Cancer Survival Better Than Blood Biomarkers AI analysis of serial facial photos in 1,000+ cancer patients found that computed facial aging rate independently predicted five-year survival with a hazard ratio of 2.1 — outperforming CRP and other standard blood markers. Dave covers what the AI is actually reading in those photos, why your face is a more accurate biological ledger than most labs your doctor orders, and the free monthly habit that turns this into an early warning system.

Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience.  -Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and one of the most credible voices in oxygen therapy and red light therapy. Brad didn't come to this work through a lab. He came to it through desperation. After battling autoimmune arthritis, melanoma, and Lyme disease, he rebuilt his health from the ground up starting in 2016 by targeting mitochondrial function when he could barely walk. Eighteen months later, he founded One Thousand Roads to bring these tools to everyone still searching for a way out. Together, Dave and Brad break down the unified theory behind oxygen therapy and red light therapy, two of the most powerful and underrated tools in biohacking. They go deep on pseudo-hypoxia, the condition where your blood oxygen looks fine but your tissues are starving, and explain why this hidden dysfunction sits at the root of chronic fatigue, inflammaging, fibromyalgia, long COVID, and poor sleep optimization. They also cover the endothelium, nitric oxide, arterial stiffness, pulse wave velocity, and why your morning biology might be the most honest readout of your metabolic health. This is essential listening for anyone serious about longevity, anti-aging, brain optimization, functional medicine, mitochondria, metabolism, and smarter not harder approaches to human performance. You'll Learn: What EWOT is and why elite athletes and biohackers use it to flood tissues with oxygen in 15 minutes How pseudo-hypoxia silently blocks energy production and drives chronic illness Why stacking red light therapy immediately after EWOT multiplies results for both How mitochondrial dysfunction connects to endothelial aging, microcirculation failure, and systemic inflammation The role of nitric oxide in arterial flexibility, vasodilation, and real anti-aging markers like pulse wave velocity Why your lungs are your biggest detox organ and how oxygen therapy supports that process How ketosis, fasting, and cellular energy interact with EWOT and red light for maximum benefit

If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Cynthia Thurlow, a nurse practitioner, CEO and founder of the Everyday Wellness Project, and a globally recognized expert in intermittent fasting and women's hormonal health. Her TEDx talk on intermittent fasting has surpassed 10 million views, and she brings over 20 years of functional medicine clinical experience to one of the most underserved conversations in longevity and human performance. Together, they tear apart the outdated medical narrative around perimenopause and menopause, exposing how a lack of knowledge, not biology, is destroying relationships, careers, and quality of life for millions of women. Dave and Cynthia dig into the gut microbiome's role in every symptom women experience in midlife, the mold toxin that is 10,000 times more potent than human estrogen and directly linked to hormonal chaos, and why biohacking your hormones as early as 35 could be the most important longevity move a woman makes. They also cover why statins are wrecking women's metabolism, how trauma accelerates ovarian aging and mitochondrial decline, the surprising connection between histamine reactions and hot flashes, and why GLP-1 micro-dosing alongside hormone replacement therapy is a game-changer for body composition and anti-aging. This episode is essential for listening for anyone serious about biohacking, sleep optimization, functional medicine, longevity, brain optimization, supplements, metabolism, human performance, and smarter not harder approaches to women's health. You'll Learn: Why perimenopause actually begins around age 35 and what to do about it before symptoms hit How a mold-derived xenoestrogen found in conventional beef disrupts hormones at 10,000 times the potency of human estrogen The gut microbiome changes that drive hot flashes, brain fog, weight gain, and mood disorders in perimenopause Why oral micronized progesterone beats topical for sleep optimization and hormonal stability How testosterone drives executive function, motivation, and brain optimization in women The lab tests every woman in perimenopause should run, including fasting insulin, ApoB, ferritin, and a full thyroid panel Why adverse childhood events and unresolved trauma age the ovaries and tank mitochondria How mold toxicity and Lyme disease create a hormonal perfect storm that no amount of supplements will fix The real reason 70 perce

When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong.It's actually your immune cells suffocating on toxic waste because their power plants—your mitochondria—are breaking down.In this video, I explain the exact biological mechanism behind "immune aging" and why your body's natural cleanup system (mitophagy) stalls out in your 40s and 50s. More importantly, I'm sharing the breakthrough compound scientists discovered that actually reverses this. It's a molecule called Urolithin A, originally found in pomegranates.I dive into the massive problem with trying to get this molecule from food (only 30% of people have the right gut bacteria to even make it), and the 15 years of human clinical trials behind Mitopure—the supplement that bypasses your gut completely. I even share why I spent $100,000 on an extreme T-cell procedure before I knew I could just take this to get a younger immune system in 28 days.00:00 – Immune Decline After 4000:39 – Why Immune Cells Weaken01:17 – The Role of Mitochondria02:25 – Mitophagy & Its Decline05:45 – The Ancient Fruit: Pomegranates06:39 – The Problem With Pomegranates07:19 – Urolithin A as a Supplement08:33 – Trial Results09:58 – About MitoPure10:46 – Call to ActionThank you to our sponsors!-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air.-Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVEConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Y

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From the peptide science behind the purge to the biohacking case for voluntary pain, this conversation will change how you think about healing, resilience, and human performance.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Caitlin Thompson is an internationally recognized Kambo practitioner and educator who has guided over 2,700 clients through this medicine, with a focus on Lyme disease, autoimmune conditions, and chronic illness. Her path into this work was shaped by her own recovery from Lyme disease and Lupus. Trained in neurobiology and rooted in psychedelic science, immune health, and the human microbiome, Caitlin is currently pioneering some of the first prospective human studies on Kambo. She collaborates directly with indigenous Amazonian communities including the Matsés, Shuar, Quechua, and Matis, and has appeared on over 100 podcasts and conferences as a leading voice at the intersection of traditional medicine and modern science. Dave and Caitlin break down the full Kambo experience, from the transdermal burns and peptide families flooding your lymphatic system, to the purge, the frog face, and the window of clarity that follows. They explore why the suffering is not a side effect but the actual mechanism, how ordeal medicine builds the same neuroplasticity and dopamine receptor sensitivity that meditation, breathwork, and ice baths produce, and why this ancient practice is becoming one of the most talked about tools in functional medicine and longevity circles. They also dig into the sustainability crisis threatening frog populations in the Amazon, the almost nonexistent research landscape for Kambo, why journals refuse to publish positive findings, and how AI may unlock the ability to synthesize Kambo peptides and remove the dependency on frogs entirely. You'll Learn: Why intentional suffering through Kambo may be one of the most effective biohacking tools for immune reset and brain optimization How Kambo peptides interact with your mitochondria, vagal nerve, and immune system to drive deep healing Why the purge is not a side effect but a keystone mechanism of the medicine How ordeal medicine builds dopamine receptor sensitivity and neuroplasticity similar to fasting, cold exposure, and breathwork What the actual risks of Kambo

Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age. -Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Tommy Wood, one of the most credentialed minds working at the intersection of brain optimization, human performance, and longevity. Dr. Wood holds a medical degree from the University of Oxford, a PhD in physiology and neuroscience from the University of Oslo, and serves as Associate Professor of Pediatrics and Neuroscience at the University of Washington School of Medicine. He has published over 100 scientific papers, consulted with Olympians and world champions across more than a dozen sports, and worked directly with Formula 1 drivers to sustain elite focus and reaction time at 200 miles per hour. His forthcoming book, The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age, is the culmination of decades of research and real-world application. Together, Dave and Dr. Wood dismantle the myth that cognitive decline is inevitable, exposing how societal expectations become self-fulfilling prophecies and how the tools of biohacking, including sleep optimization, neuroplasticity training, nootropics, supplements, and strategic exercise, can dramatically shift your brain's long-term trajectory. They dig into the 3S Model of brain health (Stimulus, Supply, Support), the Yerkes-Dodson arousal curve and what it means for focus and flow states, and the surprising truth about AI, boredom, and what actually happens to your brain when you let ChatGPT do your thinking for you. This episode is essential listening for anyone serious about anti-aging, brain optimization, functional medicine, metabolism, human performance, and getting smarter without working harder. You'll Learn: Why cognitive decline is largely a self-fulfilling prophecy driven by expectation, not biology How the 3S Model (Stimulus, Supply, Support) determines your brain's long-term health and resilience What Formula 1 drivers teach us about arousal, flow states, and peak cognitive performance Why high-intensity interval training produces dramatically greater neuroplasticity benefits than Zone 2 cardio alone How creatine, nicotine, nootropics, and other supplements actually affect the aging brain The real data on alcohol, dementia risk, and what "occasional drinking" actually means scientifically How to use AI tools like ChatGPT in a way that builds brain function instead of destroying it Why boredom is a neurologica

You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology.  -Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Jason Fung, a New York Times bestselling author, practicing nephrologist, and one of the most trusted voices in functional medicine and metabolic health. Dr. Fung completed medical school at the University of Toronto and a fellowship in nephrology at Stanford University. He is the author of multiple critically acclaimed books including The Obesity Code, The Diabetes Code, and his newest release The Hunger Code, and is the co-founder of The Fasting Method, a program designed to help people lose weight and reverse type 2 diabetes through fasting and real food nutrition. His work has helped millions break free from calorie restriction dogma for good. Together, Dave and Dr. Fung expose the three types of hunger driving the obesity epidemic, why calorie restriction fails almost every time, and what ultra-processed foods actually do to your brain's reward system. They get into the real science of fasting, metabolism, hormonal signaling, GLP-1 drugs, food addiction, conditioned eating behavior, and how your physical environment is quietly sabotaging your results. If you are serious about biohacking your hunger, optimizing your body composition, and taking control of your biology without white-knuckling willpower, this episode delivers the tools you need. This is essential listening for anyone focused on biohacking, longevity, human performance, fasting, metabolism, anti-aging, sleep optimization, brain optimization, functional medicine, and eating smarter not harder. You'll Learn: Why calorie restriction fails and what actually controls how much you eat The three types of hunger: homeostatic, hedonic, and conditioned, and how each one drives overeating How ultra-processed foods hijack your dopamine system and destroy satiety signals Why wiring your jaw shut or cutting your stomach still does not produce long-term weight loss What GLP-1 drugs like Ozempic actually reveal about hunger, metabolism, and the body fat thermostat How conditioned hunger works like Pavlov's dogs and practical strategies to reverse it The role of your physical environment in controlling food noise and cravings Why food addiction is real, and which foods are engineered to keep you hooked How fasting resets hunger signals, improves metabolic flexibility, and supports ketosis The mindset shift t

I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked.After 18 months of low-calorie dieting and 700+ hours in the gym with zero fat loss, I discovered the truth about saturated fat, intermittent fasting, and why putting butter in my coffee every morning changed everything. This is the foundation of the Bulletproof Diet... and it's helped people around the world lose over a million pounds.In this video I break down 9 weight loss myths that are keeping you fat and tired:Why saturated fat is NOT bad for you (and what the real science says)The truth about low-fat diets and why they wreck your hormonesWhy counting calories is the wrong tool for fat lossHow intermittent fasting and butter coffee keep you in fat-burning mode all dayThe anti-nutrients hiding in "healthy" vegetables, whole grains, and fruitWhy 20 minutes of exercise per week beats 6 days in the gymWhether you're struggling with stubborn belly fat, constant cravings, brain fog, or low energy... this video is for you. I cover grass-fed butter benefits, MCT oil, biohacking for weight loss, leptin resistance, insulin sensitivity, autophagy, and the real reason the low-fat movement made America sicker.0:00 – Introduction03:14 – Myth #1: Saturated Fat Is Bad for You05:03 – Myth #2: Low-Fat Diets Are Healthy07:01 – Myth #3: Cutting Calories Is the Key to Fat Loss08:53 – Myth #4: Eating Small Meals Boosts Your Metabolism10:24 – Myth #5: All Vegetables Are Good for You12:10 – Myth #6: Whole Grains Are Healthy13:26 – Myth #7: Fruit Is Always Healthy14:42 – Myth #8: You Need to Eat Breakfast Right Away15:56 – Myth #9: Exercise Is the Best Way to Lose WeightThank you to our sponsors!Neuronic | Go to www.neuronic.online Code DAVE for $100 offSuperstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/daveiRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybpr

This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy—why cancer cells can't mount antiviral defenses that healthy tissue can—and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology. Sources: -https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer -https://www.eurekalert.org/news-releases/1116087 -https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/  ***Spermidine is the Missing Link Between Fasting and Longevity*** A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine—blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shiitake mushrooms, fermented foods), and how to time supplementation for maximum autophagy activation. This is the most critical missing variable in fasting-focused biohacking that almost no one is tracking. Sources: -https://www.nature.com/articles/s41556-024-01468-x -https://pubmed.ncbi.nlm.nih.gov/39117797/ -https://oxfordhealthspan.com/blogs/aging-well/spermidine-and-healthy-aging-insights-from-a-2026-nature-review<

Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Grab a generous discount on your next purchase of Active Skin Repair by using code ‘Dave’ at: https://www.activeskinrepair.com  Host Dave Asprey sits down with Justin Gardner, a 20-year leader in health, wellness, and regenerative medicine who has founded and sold multiple companies and introduced over 50 innovative products into hospitals and doctors' offices. When Justin discovered hypochlorous acid, he shifted his entire focus to making this medical-grade, non-toxic molecule available to the public, founding Active Skin Repair to give people a cleaner, more effective alternative to the chemical-laden products that dominate the skincare aisle. Dave and Justin cover the full biohacking case for HOCl: how it kills 99.9% of bacteria, viruses, and fungi in 15 seconds, why it does not trigger antibiotic resistance, how it avoids destroying the healthy growth factors that hydrogen peroxide nukes, and how it supports the skin microbiome instead of wrecking it. They also get into AI as a tool for functional medicine research, why the standard of care is the floor not the ceiling, and how smarter not harder approaches to wound care and chronic skin conditions are finally going mainstream. Dave shares the story of treating a mystery acid beetle wound from his Amazon trip using this exact compound, and why it belongs in every medicine cabinet alongside your supplements stack. You'll Learn: Why hypochlorous acid is 100 times more powerful than bleach but has the same safety profile as saline How HOCl mimics your immune system's own wound response instead of overriding it Why hydrogen peroxide and Neosporin can actually stall healing and damage your skin microbiome How HOCl disrupts biofilms in chronic wounds, sinuses, and on the skin during eczema flare-ups Why most HOCl products on the market contain little to no active ingredient How to use AI tools like Claude and Perplexity for functional medicine research that most doctors haven't done Why the US standard of care is the floor, not the ceiling, for anyone serious about longevity and anti-aging How to stack HOCl with red light therapy and other biohacking tools for faster recovery <stro

The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Jim O'Neill served as Deputy Secretary of Health and Human Services and Acting Director of the CDC before being nominated to lead the National Science Foundation in March 2026. Before entering government, he was CEO of SENS Research Foundation, where he led cutting-edge regenerative medicine research targeting mitochondrial mutations, senescent cells, and neocortex rejuvenation. He is a 30-year veteran of health care reform and a genuine longevity insider. Dave and Jim cover the complete rewrite of federal dietary guidelines, the government's new randomized controlled trials on saturated fats, and why grains are no longer the core of a "balanced diet." They dig into a 144 million dollar ARPA H program to establish causal aging biomarkers that will unlock real anti-aging drug development and accelerate the kind of longevity research the SENS Foundation pioneered. Jim explains why current aging clocks and DNA methylation markers are not enough, and what comes next for functional medicine, sleep optimization, and metabolism research. They also break down the CDC's return to its infectious disease core, the future of AI in health care, wearable data for disease surveillance, organ bioprinting, GLP-1s, supplements like vitamin D, peptides, and the right to self-experiment. You will learn: Why the new federal dietary guidelines finally reject grain-centric nutrition and validate what the biohacking world has argued for 25 years How a 144 million dollar government program aims to build the causal biomarkers that will make real anti-aging and longevity drug development possible What Jim thinks about DNA methylation clocks and why better tools are needed to measure aging and human performance How AI is reshaping prescription refills, clinical decision support, Medicare reimbursement, and the future of functional medicine Why Jim wears an Oura Ring and uses sleep optimization data to make daily health decisions The government's evolving stance on peptides, supplements, and therapies that are not patent protected How organ bioprinting using a patient's own cells could solve the organ shortage crisis What real science replication looks like and why the government is now funding it What the CDC is doing to refocus on infectious disease while shedding mission creep How GLP-1s, fitness tracking, and updated nutritio

My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDSCreatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades. Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization. Timestamps:0:00 – Introduction1:14 – Why Creatine Matters5:01 – History of Creatine6:09 – Debunking the Myths8:55 – 5 Ways Creatine Fuels Your Mind & Body16:25 – How to Maximize Absorption18:13 – Dosing: How Much & When to Take It19:07 – Forms of Creatine Explained19:50 – Special Use Cases21:28 – Biohacking Real-World Applications23:21 – What to Stack with Creatine24:50 – Choosing the Right Creatine28:40 – Recap & Key TakeawaysThank you to our sponsors! Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy

This week's stories: *Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a conventional doctor's radar, and the specific PCR protocol you need to actually find it. Sources: https://pubmed.ncbi.nlm.nih.gov/  *High Tyrosine Levels May Be Cutting Years Off Men's Lives A Mendelian randomization study of 270,000 UK Biobank participants found that elevated tyrosine is causally linked to nearly a full year of lost lifespan in men — with zero effect in women. The culprit appears to be an inflammatory oxidation pathway that men metabolize very differently. Dave examines what this means for every guy stacking L-tyrosine nootropics or eating high-protein keto. Sources: https://pubmed.ncbi.nlm.nih.gov/41045493/ https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men https://www.usnews.com/news/health-news/articles/2026-02-27/study-suggests-one-common-amino-acid-may-affect-how-long-men-live  *Blue Light Blocking Contact Lenses Are a Legitimate Vision Upgrade ALTIUS Vision's tinted contact lenses aren't just blue light filters — they cut chromatic aberration by 53% and improve motion tracking and contrast sensitivity in ways that software filters simply can't replicate. Dave covers the mechanism, who benefits most (screen workers, TBI recovery, gamers), and how to find a provider. Sources: https://altiusvision.com/chromatic-aberration/ https://altiusvision.com/science-of-altius/ https://www.westvalleyvision.com/-altius--performance-tinted-contact-lenses  *Taurine Plus B Vitamins Actually Moves the Needle on Motivation A randomized crossover trial found that a daily stack of tauri

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today. Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s. You'll Learn: Why vaginal hormone delivery outperforms every other delivery method for women How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear Why a carnivore or animal-based diet raises estrogen and why fiber lowers it How progesterone converts to testosterone in women, and why you may not need a testosterone prescription The real reason SSRIs get prescribed when hormone replacement therapy should come first Why iodine is essential for breast health, estrogen metabolism, and thyroid function How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys Why both partners need hormone replacement therapy for a relationship to thrive How hormones control mitochondria, dopamine, norepinephrine, and every system in your body Thank you to our sponsors!      - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From the peptide science behind the purge to the biohacking case for voluntary pain, this conversation will change how you think about healing, resilience, and human performance.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Caitlin Thompson is an internationally recognized Kambo practitioner and educator who has guided over 2,700 clients through this medicine, with a focus on Lyme disease, autoimmune conditions, and chronic illness. Her path into this work was shaped by her own recovery from Lyme disease and Lupus. Trained in neurobiology and rooted in psychedelic science, immune health, and the human microbiome, Caitlin is currently pioneering some of the first prospective human studies on Kambo. She collaborates directly with indigenous Amazonian communities including the Matsés, Shuar, Quechua, and Matis, and has appeared on over 100 podcasts and conferences as a leading voice at the intersection of traditional medicine and modern science. Dave and Caitlin break down the full Kambo experience, from the transdermal burns and peptide families flooding your lymphatic system, to the purge, the frog face, and the window of clarity that follows. They explore why the suffering is not a side effect but the actual mechanism, how ordeal medicine builds the same neuroplasticity and dopamine receptor sensitivity that meditation, breathwork, and ice baths produce, and why this ancient practice is becoming one of the most talked about tools in functional medicine and longevity circles. They also dig into the sustainability crisis threatening frog populations in the Amazon, the almost nonexistent research landscape for Kambo, why journals refuse to publish positive findings, and how AI may unlock the ability to synthesize Kambo peptides and remove the dependency on frogs entirely. You'll Learn: Why intentional suffering through Kambo may be one of the most effective biohacking tools for immune reset and brain optimization How Kambo peptides interact with your mitochondria, vagal nerve, and immune system to drive deep healing Why the purge is not a side effect but a keystone mechanism of the medicine How ordeal medicine builds dopamine receptor sensitivity and neuroplasticity similar to fasting, cold exposure, and breathwork What the actual risks of Kambo

I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE)Try Energy Bits: https://energybits.com/discount/daveAstronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to identify a nutrient dense enough to protect DNA and mitochondria from extreme oxidative stress. They found it in algae (spirulina and chlorella)—a superfood older than civilization that acts as "biological armor" for your cells.In this episode, I break down why "aging" is actually just a buildup of oxidative stress (cellular rust) and how most antioxidants fail to fix it because they never reach the mitochondria. I reveal the exact science behind why algae works, the specific molecules (phycocyanin and chlorophyll) that protect your cellular walls, and the protocol I use to keep my liver young and my energy stable.We also cover the critical lifestyle factors—from sleep to seed oils—that are throwing gasoline on the fire, and how to "clear the battlefield" so this superfood can actually do its jobTimestamps:00:00 – Intro01:03 – The Aging Myth01:43 – How Aging Actually Starts03:33 – Restoring Your Antioxidant Defense04:56 – Why Most Supplements Fail07:30 – NASA's Superfood Discovery11:47 – How to Use Algae13:24 – Lifestyle Factors That Undermine Algae15:57 – Action PlanThank you to our sponsors!Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off.The One Device | Use code DAVE for $10 off at theonedevice.com/dave.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at <a href="https://art19.com/privacy" re

Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave Host Dave Asprey sits down with Seth Jones, CEO of Superstratum and the creator of the first patent-pending process to remove mycotoxins from homes. Before founding Superstratum, Seth spent 15 years as an international songwriter, producer, and DJ until a personal experience with Building-Related Illness changed the entire direction of his life. Today he and his team are on a mission to heal the estimated 66 million homes in the U.S. that create toxic conditions for the 170 million people living inside them. If toxic mold has derailed your health, your relationships, or your ability to think clearly, this conversation will change how you see your home forever. Dave Asprey built his entire biohacking and longevity career trying to fix what mold did to his body. By his mid-twenties, he carried diagnoses of arthritis, chronic fatigue, fibromyalgia, and mold-induced brain damage that wiped out his prefrontal cortex activity. Functional medicine doctors couldn't help him. Specialists gave up. It took him years of self-directed research into mitochondria, metabolism, and environmental toxicology to understand that his home was the root cause. He lost 100 pounds, reversed brain damage confirmed by imaging, and recovered IQ points he thought were gone for good. In this episode, Dave and Seth break down the real science of how mycotoxins poison mitochondria, hijack hormones, crush sleep optimization, and block the neuroplasticity your brain needs to perform. They reveal why mold is additive with every other toxin in your environment, why most remediation fails, and how a systematic home detox protocol can do what no supplement, nootropic, or fasting protocol can fix on its own. You'll Learn: Why mold toxins are direct mitochondrial poisons and what that means for your energy, willpower, and metabolism How mycotoxins lower your IQ by up to 15 points and why removing them reverses the damage The estrogen-mimicking mold toxin 10,000 times stronger than human estrogen that causes weight gain no diet can fix Why your AC and HVAC system are the most dangerous mold delivery systems in your home How mold disables detox pathways and makes every other environmental toxin worse The connection between toxic mold, Lyme disease, Alzheimer's, cancer, and fertility loss Why Danger Coffee and mold-free nutrition matter as much as fixing your home The step-by-step Superstratum protocol for fogging, bombing, coating, and restoring a healthy home microbiome

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen. Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force veteran, and founder of Autism Health, a 501(c)(3) nonprofit organization dedicated to accelerating biomedical solutions for autism. Tracy has spent over 17 years researching treatments and therapies for autism and other neurological disorders, trained in complementary and alternative medicine, and built the Autism Health Summit into one of the most important annual gatherings for parents, physicians, and researchers in the autism recovery space. She is not a researcher observing from a distance. She is a mother who sold everything she owned, bartered for treatments, and traveled to Ukraine for stem cell therapy to recover her son Noah, who today lives a fully independent life, works full time, and travels the world alone. Together, Dave and Tracy tear apart the myth that autism is a fixed genetic condition and expose it for what it actually is: a biological cascade triggered by a recipe of environmental factors colliding with genetic susceptibility. They cover how mitochondrial dysfunction and chronic neuroinflammation combine to create the sensory overload and cognitive fog that defines autism, why healing the gut first is the non-negotiable foundation that determines whether every other treatment works, how glyphosate, toxic mold, heavy metals, volatile organic compounds, and vaccine injury each contribute to a compounding toxic load that crosses the threshold into autism, why plasmalogen supplements are producing results in non-speaking children that the medical establishment insists are impossible, and how AI is now accelerating the ability of parents and practitioners to identify personalized biological pathways and act on them in hours instead of months. Dave also shares his own journey reversing Asperger's syndrome over ten years through biology, mitochondrial repair, neuroplasticity retraining, and supplements, and explains why catching these conditions early and acting on them aggressively with functional medicine is the difference between a life of suffering and a life of superpowers. You'll Learn: Why autism is biological, not purely genetic, and what environmental triggers pull the trigger on susceptible children How mitochondrial collapse creates the energy deficit that drives sensory overload, social withdrawal, and cognitive dysfunction in autism Why healing the gut first determines whether every other autism treatment works or fails What plasmalogen su

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Grab a discount on Puori Products by visiting: https://puori.com/pages/dave?dt_id=1750934 Host Dave Asprey sits down with Oliver Amdrup-Chamby, founder and CEO of PUORI and a serial entrepreneur in the health and wellness space with over 16 years building what has become one of the most rigorously tested supplement brands in the world. Oliver opened the first CrossFit gym in Denmark in 2006, served as Regional Director of CrossFit HQ across Europe and the Middle East, holds an Executive Program credential from Stanford, and advises longevity projects including One Thirty Labs in Copenhagen. He founded PUORI in 2009 with a single obsession: creating the cleanest third-party tested fish oil on the market. That obsession grew into a full supplement line built on batch testing every finished consumer product for environmental toxins, a standard the industry has yet to catch up to. Together, Dave and Oliver expose the hidden contamination crisis inside the supplement industry, from oxidized fish oil that creates inflammation instead of fighting it, to plant-based protein powders carrying up to 10 times more heavy metals than whey. They break down why organic does not mean safe, how glyphosate embeds itself directly into your collagen infrastructure and disrupts the body's ability to build healthy connective tissue, and why the omega 3 index is one of the most powerful and measurable longevity biomarkers you are probably ignoring. They also dig into the surprising brain optimization and anti-aging benefits of creatine, including new research on concussion recovery and sleep deprivation, and how foundational supplements like vitamin D, magnesium, and high-quality fish oil remain the non-negotiables that no nootropic stack can replace. You'll Learn: Why organic protein powder often contains more heavy metals than non-organic options How glyphosate infiltrates collagen and gets rebuilt into your body's own tissue What the omega 3 index is, why most Americans are dangerously low, and how raising it correlates with years of additional longevity Why plant-based omega 3s fail to convert to DHA and what to take instead How oxidized fish oil creates inflammation rather than reducing it, and what to look for on the label </l

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if your brain is electrically "awake," you will stay "tired but wired."The "switch" I use to fix this is an amino acid called L-theanine. It crosses the blood-brain barrier to increase Alpha waves, which quiet the prefrontal cortex and stop overthinking. By boosting GABA and lowering glutamate, it prepares the brain for rest without the groggy "hangover" of traditional sedatives.To make this work, I follow a strict protocol: taking 400mg–1000mg about 45 minutes before bed on an empty stomach. I also protect my "Alpha state" by blocking blue and green "junk light" with TrueDark glasses, which prevents cortisol spikes that ruin sleep architecture. When you combine the right compounds with a dark, low-stimulation environment and consistent timing, sleep stops being something you chase and becomes something your body does automatically.Timestamps:00:00 – Introduction00:23 – How the Brain Enters Sleep01:00 – Why Most Supplements Fail02:15 – Beta Waves: The Sleep Blocker03:29 – Alpha Waves: The Sleep Gateway04:51 – The Amino Acid That Shifts Your Brain06:11 – Introducing L-Theanine06:48 – Common L-Theanine Mistakes08:02 – The Right Protocol09:34 – Light & Your Sleep Environment11:13 – Fixing Your Light Environment12:14 – The Full Sleep System13:59 – Putting It All TogetherThank you to our sponsors!AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/hea

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision.  - Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. You'll Learn: How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot Why cell viability and placement

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness. Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere. This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for. You'll Learn: Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety The six scientifically backed ways to open your right brain and unlock experiences of real meaning Why self-improvement fails without first understanding the neuroscience of how ideas inst

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. You'll Learn: Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine Thank you to our sponsors!    Suppgrade Labs | G

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.To reverse this, I use 7 specific daily habits to flip the self-healing switch:- Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.- Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.- Mechanical Rest: I practice "Eye Fasting"—looking at true distance—to release the mechanical tension of constant near-focus.- Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.- Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.- Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.- Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.Timestamps:00:00 – Intro01:05 – The Problem with Traditional Vision Care02:48 – How Your Eyes Repair Themselves at Night05:03 – How Modern Life Breaks the Repair Cycle05:53 – The 7 Habits to Activate Your Eye's Self-Healing Switch06:07 – Habit 1: Red Light Therapy07:18 – Habit 2: Blueberries and Rhodopsin09:22 – Habit 3: Cold Exposure for Blood Flow11:10 – Habit 4: Grounding to Reduce Oxidative Stress13:38 – Habit 5: Eye Fasting (Distance Viewing)15:45 – Habit 6: Deliberate Blinking17:53 – Habit 7: Sunset Light and Circadian RepairThank you to our sponsors!--Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources:  -https://www.nbc.com/saturday-night-live  -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources:  -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/  *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources:  -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/  *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not spe

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care. Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino. This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology. You'll Learn: Why testing TSH alone misses thyroid dysfunction in the vast majority of people What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3 Why T4-only medications like Synthroid fail and what works better How low thyroid directly tanks testosterone and libido in both men and women The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods How Hashimoto's connects to broader autoimmune risk and what drives it into remission Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes When to use T3 only vs. a T3/T4 combination, and how

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ Jason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies. Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing. You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness. You will Learn: Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System How encoded light affirmations restructure the molecular formation of water in your body without conscious effort What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them How full spectrum visible light maps directly onto the body's energy centers and organ systems Why the metamatrix font used in The Light System produces stronger biological effects than standard text How this technology was invented by a programmer combining tran

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/Timestamps:00:00 - The Anti-Aging Switch01:30 - Chronological vs. Biological Age02:32 - How Aging Works at the Cellular Level04:58 - 43 Ways to Upgrade Your Mitochondria07:37 - What Is Autophagy09:17 - The Stages of Fasting10:46 - What Happens During a 3-Day Fast13:04 - How to Fast Correctly14:42 - Breaking the Fast15:58 - The Power of SubtractionThank you to our sponsors!-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. Sources: https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance  Bats Are Breaking the Telomere Model A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing. Sources: https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 https://www.nature.com/articles/telomere-bat-aging-2026 The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sens

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors!    Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to <a href

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences. Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity. You'll Learn: Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit How your mitochondria pre-process sensory reality before your auditory cortex even fires Why emotions like anger, love, and remorse are computational tools evolution built into your reward function How low energy and blood sugar directly degrade your decision-making at a hardware level What "resource rationality" means and how to use it to make better decisions under constraint Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head How neuroplasticity can eliminate the inner critic and reshape your mental operating system Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence  Thank you to our sponsors!  -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.-Quantum Upgrade | Try it free for 15 days — no credit card required — at <a href="http://quantumupgrade.io/DAVE" rel="noopener noref

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBEThink 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it.Thank you to our sponsors! -Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com  Chapters:0:00 – Introduction0:38 – The Real Reason You're Still Tired0:59 – How Light Controls Your Sleep Quality1:36 – Circadian Rhythm Explained (NASA-Approved)2:51 – The Secret Sleep Trigger5:29 – Blue Light: The Silent Sleep Killer6:12 – How to Hack