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Talk Python To Me

Michael Kennedy·554 episodes

TechnologyInterview showPython ecosystemWeekly1 hr/epDeveloper-focusedEnglish

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

Why listen

Talk Python To Me gives Python developers direct, practical conversations with the people building the tools they actually use. Michael Kennedy interviews package authors, framework creators, core contributors, data scientists, and infrastructure engineers, so each episode feels like a guided tour through a real corner of the Python ecosystem. It is especially useful for working developers who want to keep up with Python packaging, web frameworks, data tools, AI workflows, security, and production practices without chasing every blog post themselves.

Episodes

1 hr 4 min
Jul 13, 2026Episode 555
Marimo Pair - A Canvas for Agent + Developers Collaboration

Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state. This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show marimo pair: marimo.io/pair Course transcripts announcement: talkpython.fm/blog anywidget: Jupyter Widgets made easy: talkpython.fm marimo: marimo.io blog: marimo.io GitHub: github.com given this: martinalderson.com llms.txt: talkpython.fm mcp: talkpython.fm cli: talkpython.fm open issues: github.com Discord: marimo.io Marimo Pair: marimo.io <s

1 hr
Jul 10, 2026Episode 554
Trustworthy AI in Healthcare and Longevity

You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it. Episode sponsors Six Feet Up Talk Python Courses Links from the show Guest Sumit Gundawar: linkedin.com Course transcripts announcement: talkpython.fm/blog Sumit Gundawar - JAX London Speaker: jaxlondon.com Anthropic: anthropic.com OpenAI Platform: platform.openai.com Anthropic: anthropic.com LangChain: langchain.com OWASP: owasp.org Pydantic: pydantic.dev EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu HIPAA - HHS: www.hhs.gov NHS: www.nhs.uk Llama: llama.com Qwen - QwenLM on GitHub: githu

55 min
Jun 26, 2026Episode 553
All of our tools

This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show @[email protected]: sixfeetup.social @calvinhp.com: bsky.app calvinhp.com: calvinhp.com Original airing on Python Bytes: pythonbytes.fm pi: pi.dev superpowers: github.com Warp.dev: Warp.dev OhMyZSH: ohmyz.sh Commandbookapp.com: Commandbookapp.com Blink: blink.sh kitty: sw.kovidgoyal.net mosh: mosh.org tmux: github.com Claude code: www.anthropic.com Claude.md: Claude.md MacWhisper</stron

1 hr 5 min
Jun 17, 2026Episode 552
Astral joins OpenAI

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show Guest Charlie Marsh: github.com The announcement: astral.sh OpenAI: openai.com uv: github.com ty: github.com Ruff: github.com pyx: astral.sh Codex team: openai.com Anthropic did something similar by acquiring Bun: www.anthropic.com Daily Stars Explorer: emanuelef.github.io Agentic AI Programming for Python: training.talkpython.fm Python Web Security: OWASP Top 10 with Agentic AI: training.talkpython.fm Episode #552 deep-dive: talkpython.fm/552 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: <a href="https://talkpython.fm/flaskso

1 hr 48 min
Jun 11, 2026Episode 551
Stroll Down Startup Lane - 2026

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk. Episode sponsors AgentField AI Talk Python Courses Links from the show Guests Naunidh Bhalla: linkedin.com Grant Gittes: linkedin.com Marcel Kornacker: linkedin.com Beon de Nood: linkedin.com Chinmaya Joshi: linkedin.com David Mytton: linkedin.com Shea Tate-Di Donna: linkedin.com Jason Rowley: linkedin.com Azul Garza: github.com Renée Rosillo: linkedin.com Tetrix: tetrix.co Tetrix Jobs: tetrix.co Arcjet: <a href="https://arcjet.com/?fea

1 hr 2 min
May 30, 2026Episode 550
AI Contributions and Maintainer Load in Open Source

You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please review this for me." Over the past year, GitHub activity has spiked roughly twelve times in a few short months, and a huge chunk of that signal is landing on the same small group of maintainers who were already stretched thin. The curl bug bounty got buried under AI-generated noise. Jazzband, the home of Django classics like pip-tools and the Django debug toolbar, hit what its maintainer called an "apocalypse" and started sunsetting. Even CPython just shipped fresh guidelines on AI-assisted contributions this week. So what does all of this actually look like from the receiving end of the pull request? On this episode, Paolo Melchiorre joins us to tell that story from inside the maintainer's chair. Paolo is a director of the Django Software Foundation, an organizer of PyCon Italy, a Django Girls coach, and he has spent the past year carefully collecting examples of how AI is reshaping open source contributions. The good, the bad, and the extra fingers. We dig into his PyCon US talk on AI-assisted contributions and maintainer load, why AI is best understood as an amplifier rather than a new kind of contributor, the wildly different policies across 86 open source foundations, whether projects banning AI today are reacting to last year's models. Episode sponsors AgentField AI Talk Python Courses Links from the show Guest Paolo Melchiorre: github.com DSF: www.djangoproject.com djangonaut-space: djangonaut.space PyCon Italia: 2026.pycon.it uDjango: github.com My PyCon US 2026 post: www.paulox.net AI-Assisted Contributions and Maintainer Load: www.paulox.net Senior Engineer Tries Vibe Coding: www.youtube.com Code

1 hr 7 min
May 25, 2026Episode 549
Great Docs

Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a brand new Python documentation tool called Great Docs that takes both seriously. Rich is the creator of Great Tables, and before that the R package GT, the man has a serious eye for design, and he's pointed that energy at the Python docs ecosystem. We'll talk about how Great Docs spins up a polished site in three commands, why every page ships as Markdown for your favorite LLM, how it leans on Quarto for executable code blocks and tabbed install sections, and where it lands against Sphinx, MkDocs, and Zensical. Plus, you'll meet Tablin. Here we go. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guests Michael Chow: github.com Rich lannone: github.com Python Web Security with OWASP Top 10 and Agentic AI Course: talkpython.fm Great Docs: posit-dev.github.io/great-docs Great Tables: posit-dev.github.io GT Episode: talkpython.fm Sphinx: www.sphinx-doc.org mkdocs: www.mkdocs.org Zensical: zensical.org Hugo: gohugo.io Ghost: ghost.org Rs pkgdown: pkgdown.r-lib.org Quarto: quarto.org quickstart: <a href="https://posit-dev.github.io/great-docs/user-guide/quickstart.html?featured_on=ta

1 hr 8 min
May 11, 2026Episode 548
Event Sourcing Design Pattern

What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly forgets its own history. That's event sourcing, and Chris May is back on Talk Python, fresh off our Datastar panel, to walk us through what it actually looks like in Python. We'll cover the core patterns, the libraries to reach for, when not to use it, and why event sourcing turns out to be a surprisingly good fit for AI-assisted coding. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guest Chris May: everydaysuperpowers.dev Intro to event sourcing e-book: everydaysuperpowers.gumroad.com Domain-Driven Design: The Power of CQRS and Event Sourcing: How CQRS/ES Redefine Building Scalable System: ricofritzsche.me DDD: www.amazon.com Understanding Eventsourcing (Martin Dilger): www.amazon.com Event Sourcing Explained using Football Video: www.youtube.com Why I finally embraced event sourcing and why you should too article: everydaysuperpowers.dev valkey: valkey.io diskcache: talkpython.fm<

59 min
May 6, 2026Episode 547
Parallel Python at Anyscale with Ray

When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkeley research lab lineage that gave us Apache Spark. And here's the twist: Ray was originally built for reinforcement learning research, then quietly faded as RL hit a wall. Until ChatGPT showed up. Suddenly reinforcement learning was back, as the post-training step that turns a raw language model into something genuinely useful. Edward Oakes and Richard Liaw, two founding engineers behind Ray and Anyscale, join me on Talk Python to tell that story. We'll trace Ray from its RISE Lab origins at UC Berkeley to powering some of the largest training runs in the world. We'll talk about what Ray actually is, a distributed execution engine for AI workloads, and how a few lines of Python become work running across hundreds of GPUs. We'll cover Ray Data for multimodal pipelines, the dashboard, the VS Code remote debugger, KubRay for Kubernetes, and where Ray fits alongside Dask, multiprocessing, and asyncio. If you've ever stared at a single-machine Python script and thought, "there has to be a better way to scale this", this one's for you Episode sponsors Sentry Error Monitoring, Code talkpython26 AgentField AI Talk Python Courses Links from the show Guests Richard Liaw: github.com Edward Oakes: github.com Ray: www.ray.io Example code (we used for walk-through): docs.ray.io Getting Started with Ray: docs.ray.io Ray Libraries: docs.ray.io kuberay: github.com Watch this episode on YouTube: youtube.com Episode #547 deep-dive: talkpython.fm/547

1 hr 3 min
Apr 27, 2026Episode 546
Self hosting apps for Python people

The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?" My guest this week is Alex Kretzschmar, head of DevRel at Tailscale, longtime host of the Self-Hosted podcast, and co-founder of Linuxserver.io. We cover what self-hosting really means in 2026, the apps worth running yourself like Immich and Home Assistant, why Docker Compose ties it all together, and how Tailscale lets you reach any of it from anywhere, without opening a single port. If you've been thinking about pulling your digital life back behind your own walls, this is your roadmap. Episode sponsors Temporal Talk Python Courses Links from the show Guest Alex Kretzschmar: alex.ktz.me Bitflip podcast: bitflip.show Self-Hosted podcast (Alex's previous show): selfhosted.show Perfect Media Server: perfectmediaserver.com KTZ Systems on YouTube: youtube.com/@ktzsystems Linuxserver.io (co-founded by Alex): linuxserver.io "How Tailscale Works" blog post: tailscale.com/blog/how-tailscale-works https://tailscale.com/: tailscale.com Self-hosted apps discussed Awesome Self-Hosted (GitHub list): github.com Immich (Google Photos alternative): immich.app Home Assistant: home-assistant.io Open Home Foundation: openhomefoundation.org Plausible A

1 hr 6 min
Apr 16, 2026Episode 545
OWASP Top 10 (2025 List) for Python Devs

The OWASP Top 10 just got a fresh update, and there are some big changes: supply chain attacks, exceptional condition handling, and more. Tanya Janca is back on Talk Python to walk us through every single one of them. And we're not just talking theory, we're going to turn Claude Code loose on a real open source project and see what it finds. Let's do it. Episode sponsors Temporal Talk Python Courses Links from the show DevSec Station Podcast: www.devsecstation.com SheHacksPurple Newsletter: newsletter.shehackspurple.ca owasp.org: owasp.org owasp.org/Top10/2025: owasp.org from here: github.com Kinto: github.com A01:2025 - Broken Access Control: owasp.org A02:2025 - SecuA02 Security Misconfiguration: owasp.org ASP.NET: ASP.NET A03:2025 - Software Supply Chain Failures: owasp.org A04:2025 - Cryptographic Failures: owasp.org A05:2025 - Injection: owasp.org A06:2025 - Insecure Design: owasp.org A07:2025 - Authentication Failures: owasp.org A08:2025 - Software or Data Integrity Failures: <a href="https://owasp.org/Top10/2025/A08_2025-Software_or_Data_Integrity_Failures/?

1 hr 11 min
Apr 10, 2026Episode 544
Wheel Next + Packaging PEPs

When you pip install a package with compiled code, the wheel you get is built for CPU features from 2009. Want newer optimizations like AVX2? Your installer has no way to ask for them. GPU support? You're on your own configuring special index URLs. The result is fat binaries, nearly gigabyte-sized wheels, and install pages that read like puzzle books. A coalition from NVIDIA, Astral, and QuanSight has been working on Wheel Next: A set of PEPs that let packages declare what hardware they need and let installers like uv pick the right build automatically. Just uv pip install torch and it works. I sit down with Jonathan Dekhtiar from NVIDIA, Ralf Gommers from Quansight and the NumPy and SciPy teams, and Charlie Marsh, founder of Astral and creator of uv, to dig into all of it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guests Charlie Marsh: github.com Ralf Gommers: github.com Jonathan Dekhtiar: github.com CPU dispatcher: numpy.org build options: numpy.org Red Hat RHEL: www.redhat.com Red Hat RHEL AI: www.redhat.com RedHats presentation: wheelnext.dev CUDA release: developer.nvidia.com requires a PEP: discuss.python.org WheelNext: wheelnext.dev Github repo: <a href="https://github.com/wheelnext?fea

1 hr 3 min
Apr 1, 2026Episode 543
Deep Agents: LangChain's SDK for Agents That Plan and Delegate

When you type a question into ChatGPT, the model only has what you typed to work with. But tools like Claude Code can plan, iterate, test, and recover from mistakes. They work more like we do. The difference is the agent harness: Planning tools, file system access, sub-agents, and carefully crafted system prompts that turn a raw LLM into something genuinely capable. Sydney Runkle is back on Talk Python representing LangChain and their new open source library, Deep Agents: A framework for building your own deep agents with plain Python functions, middleware hooks, and MCP support. This is how the magic works under the hood. Episode sponsors Sentry Error Monitoring, Code talkpython26 Agentic AI Course Talk Python Courses Links from the show Guest Sydney Runkle: github.com Claude Code uses: x.com Deep Research: openai.com Manus: manus.im Blog post announcement: blog.langchain.com Claudes system prompt: github.com sub agents: docs.anthropic.com the quick start: docs.langchain.com CLIs: github.com Talk Python's CLI: talkpython.fm custom tools: docs.langchain.com DeepAgents Examples: github.com Custom

1 hr 4 min
Mar 25, 2026Episode 542
Zensical - a modern static site generator

If you've built documentation in the Python ecosystem, chances are you've used Martin Donath's work. His Material for MKDocs powers docs for FastAPI, uv, AWS, OpenAI, and tens of thousands of other projects. But when MKDocs 2.0 took a direction that would break Material and 300 ecosystem plugins, Martin went back to the drawing board. The result is Zensical: A new static site generator with a Rust core, differential builds in milliseconds instead of minutes, and a migration path designed to bring the whole community along. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show Guest Martin Donath: github.com Zensical: zensical.org Material for MkDocs: squidfunk.github.io Getting Started: zensical.org Github pages: docs.github.com Cloudflare pages: pages.cloudflare.com Michaels Example: gist.github.com Material for MkDocs: zensical.org gohugo.io/content-management/shortcodes: gohugo.io a sense of size of the project: blobs.talkpython.fm Zensical Spark: zensical.org Watch this episode on YouTube: youtube.com Episode #542 deep-dive: talkpython.fm/542 Episode transcripts: talkpython.fm

1 hr 5 min
Mar 19, 2026Episode 541
Monty - Python in Rust for AI

When LLMs write code to accomplish a task, that code has to actually run somewhere. And right now, the options aren't great. Spin up a sandboxed container and you're paying a full second of cold start overhead plus the complexity of another service. Let the LLM loose on your actual machine and... well, you'd better be watching. On this episode, I sit down with Samuel Colvin, creator of Pydantic, now at 10 billion downloads, to explore Monty, a Python interpreter written from scratch in Rust, purpose-built to run LLM-generated code. It starts in microseconds, is completely sandboxed by design, and can even serialize its entire state to a database and resume later. We dig into why this deliberately limited interpreter might be exactly what the AI agent era needs. Episode sponsors Talk Python Courses Python in Production Links from the show Guest Samuel Colvin: github.com CPython: github.com IronPython: ironpython.net Jython: www.jython.org Pyodide: pyodide.org monty: github.com Pydantic AI: pydantic.dev Python AI conference: pyai.events bashkit: github.com just-bash: github.com Narwhals: narwhals-dev.github.io Polars: pola.rs Strands Agents: aws.amazon.com Subscribe Running Pydantic’s Monty Rust sandboxed Python subset in WebAssembly: <a href="https://simonwillison.net/2026/Feb/6/pydantic-monty/?fe

1 hr 2 min
Mar 13, 2026Episode 540
Modern Python monorepo with uv and prek

Monorepos -- you've heard the talks, you've read the blog posts, maybe you've seen a few tantalizing glimpses into how Google or Meta organize their massive codebases. But it's often in the abstract and behind closed doors. What if you could crack open a real, production monorepo, one with over a million lines of Python and over 100 of sub-packages, and actually see how it's built, step by step, using modern tools and standards? That's exactly what Apache Airflow gives us. On this episode, I sit down with Jarek Potiuk and Amogh Desai, two of Airflow's top contributors, to go inside one of the largest open-source Python monorepos in the world and learn how they manage it with uv, pyproject.toml, and the latest packaging standards, so you can apply those same patterns to your own projects. Episode sponsors Agentic AI Course Python in Production Talk Python Courses Links from the show Guests Amogh Desai: github.com Jarek's GitHub: github.com definition of a monorepo: monorepo.tools airflow: airflow.apache.org Activity: github.com OpenAI: airflowsummit.org Part 1. Pains of big modular Python projects: medium.com Part 2. Modern Python packaging standards and tools for monorepos: medium.com Part 3. Monorepo on steroids - modular prek hooks: medium.com Part 4. Shared “static” libraries in Airflow monorepo: medium.com PEP-440: <a href="https:

1 hr 1 min
Mar 6, 2026Episode 539
Catching up with the Python Typing Council

You're adding type hints to your Python code, your editor is happy, autocomplete is working great. But then you switch tools and suddenly there are red squiggles everywhere. Who decides what a float annotation actually means? Or whether passing None where an int is expected should be an error? It turns out there's a five-person council dedicated to exactly these questions -- and two brand-new Rust-based type checkers are raising the bar. On this episode, I sit down with three members of the Python Typing Council -- Jelle Zijlstra, Rebecca Chen, and Carl Meyer -- to learn how the type system is governed, where the spec and the type checkers agree and disagree, and get the council's official advice on how much typing is just enough. Episode sponsors Sentry Error Monitoring, Code talkpython26 Agentic AI Course Talk Python Courses Links from the show Guests Carl Meyer: github.com Jelle Zijlstra: jellezijlstra.github.io Rebecca Chen: github.com Typing Council: github.com typing.python.org: typing.python.org details here: github.com ty: docs.astral.sh pyrefly: pyrefly.org conformance test suite project: github.com typeshed: github.com Stub files: mypy.readthedocs.io Pydantic: pydantic.dev Beartype: github.com TOAD AI: <a href="https://gi

1 hr 12 min
Feb 28, 2026Episode 538
Python in Digital Humanities

Digital humanities sounds niche, until you realize it can mean a searchable archive of U.S. amendment proposals, Irish folklore, or pigment science in ancient art. Today I’m talking with David Flood from Harvard’s DARTH team about an unglamorous problem: What happens when the grant ends but the website can’t. His answer, static sites, client-side search, and sneaky Python. Let’s dive in. Episode sponsors Sentry Error Monitoring, Code talkpython26 Command Book Talk Python Courses Links from the show Guest David Flood: davidaflood.com DARTH: digitalhumanities.fas.harvard.edu Amendments Project: digitalhumanities.fas.harvard.edu Fionn Folklore Database: fionnfolklore.org Mapping Color in History: iiif.harvard.edu Apatosaurus: apatosaurus.io Criticus: github.com github.com/palewire/django-bakery: github.com sigsim.acm.org/conf/pads/2026/blog/artifact-evaluation: sigsim.acm.org Hugo: gohugo.io Water Stories: waterstories.fas.harvard.edu Tsumeb Mine Notebook: tmn.fas.harvard.edu Dharma and Punya: dharmapunya2019.org Pagefind library: pagefind.app django_webassembly: <a href="https://github.com/m-butterfield/django_webassemb

1 hr 16 min
Feb 21, 2026Episode 537
Datastar: Modern web dev, simplified

You love building web apps with Python, and HTMX got you excited about the hypermedia approach -- let the server drive the HTML, skip the JavaScript build step, keep things simple. But then you hit that last 10%: You need Alpine.js for interactivity, your state gets out of sync, and suddenly you're juggling two unrelated libraries that weren't designed to work together. What if there was a single 11-kilobyte framework that gave you everything HTMX and Alpine do, and more, with real-time updates, multiplayer collaboration out of the box, and performance so fast you're actually bottlenecked by the monitor's refresh rate? That's Datastar. On this episode, I sit down with its creator Delaney Gillilan, core maintainer Ben Croker, and Datastar convert Chris May to explore how this backend-driven, server-sent-events-first framework is changing the way full-stack developers think about the modern web. Episode sponsors Sentry Error Monitoring, Code talkpython26 Command Book Talk Python Courses Links from the show Guests Delaney Gillilan: linkedin.com Ben Croker: x.com Chris May: everydaysuperpowers.dev Datastar: data-star.dev HTMX: htmx.org AlpineJS: alpinejs.dev Core Attribute Tour: data-star.dev data-star.dev/examples: data-star.dev github.com/starfederation/datastar-python: github.com VSCode: marketplace.visualstudio.com OpenVSX: open-vsx.org PyCharm/Intellij plugin: <a href="https://plugins.jetbrains.com/plugi

1 hr 7 min
Feb 10, 2026Episode 536
Fly inside FastAPI Cloud

You've built your FastAPI app, it's running great locally, and now you want to share it with the world. But then reality hits -- containers, load balancers, HTTPS certificates, cloud consoles with 200 options. What if deploying was just one command? That's exactly what Sebastian Ramirez and the FastAPI Cloud team are building. On this episode, I sit down with Sebastian, Patrick Arminio, Savannah Ostrowski, and Jonathan Ehwald to go inside FastAPI Cloud, explore what it means to build a "Pythonic" cloud, and dig into how this commercial venture is actually making FastAPI the open-source project stronger than ever. Episode sponsors Command Book Python in Production Talk Python Courses Links from the show Guests Sebastián Ramírez: github.com Savannah Ostrowski: github.com Patrick Arminio: github.com Jonathan Ehwald: github.com FastAPI labs: fastapilabs.com quickstart: fastapicloud.com an episode on diskcache: talkpython.fm Fastar: github.com FastAPI: The Documentary: www.youtube.com Tailwind CSS Situation: adams-morning-walk.transistor.fm FastAPI Job Meme: fastapi.meme Migrate an Existing Project: fastapicloud.com Join the waitlist: fastapicloud.com Talk Python CLI Talk Python CLI Announcement</

1 hr 7 min
Jan 23, 2026Episode 535
PyView: Real-time Python Web Apps

Building on the web is like working with the perfect clay. It’s malleable and can become almost anything. But too often, frameworks try to hide the web’s best parts away from us. Today, we’re looking at PyView, a project that brings the real-time power of Phoenix LiveView directly into the Python world. I'm joined by Larry Ogrodnek to dive into PyView. Episode sponsors Talk Python Courses Python in Production Links from the show Guest Larry Ogrodnek: hachyderm.io pyview.rocks: pyview.rocks Phoenix LiveView: github.com this section: pyview.rocks Core Concepts: pyview.rocks Socket and Context: pyview.rocks Event Handling: pyview.rocks LiveComponents: pyview.rocks Routing: pyview.rocks Templating: pyview.rocks HTML Templates: pyview.rocks T-String Templates: pyview.rocks File Uploads: pyview.rocks Streams: pyview.rocks Sessions & Authentication: pyview.rocks Single-File Apps: <a href="https://pyview.rocks/single-file-apps/?featured_on=talkpython" t

1 hr 14 min
Jan 13, 2026Episode 534
diskcache: Your secret Python perf weapon

See the full show notes for this episode on the website at talkpython.fm/534

1 hr 1 min
Jan 5, 2026Episode 533
Web Frameworks in Prod by Their Creators

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1 hr 18 min
Dec 29, 2025Episode 532
2025 Python Year in Review

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1 hr 21 min
Dec 18, 2025Episode 531
Talk Python in Production

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1 hr 11 min
Dec 13, 2025Episode 530
anywidget: Jupyter Widgets made easy

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1 hr 17 min
Dec 3, 2025Episode 529
Computer Science from Scratch

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1 hr 16 min
Nov 30, 2025Episode 528
Python apps with LLM building blocks

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1 hr 6 min
Nov 10, 2025Episode 527
MCP Servers for Python Devs

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1 hr 7 min
Nov 1, 2025Episode 526
Building Data Science with Foundation LLM Models

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1 hr 17 min
Oct 27, 2025Episode 525
NiceGUI Goes 3.0

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1 hr 9 min
Oct 20, 2025Episode 524
38 things Python developers should learn in 2025

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1 hr 7 min
Oct 13, 2025Episode 523
Pyrefly: Fast, IDE-friendly typing for Python

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1 hr 9 min
Oct 6, 2025Episode 522
Data Sci Tips and Tricks from CodeCut.ai

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1 hr 2 min
Sep 29, 2025Episode 521
Red Teaming LLMs and GenAI with PyRIT

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1 hr
Sep 23, 2025Episode 520
pyx - the other side of the uv coin (announcing pyx)

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1 hr 2 min
Sep 18, 2025Episode 519
Data Science Cloud Lessons at Scale

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1 hr 8 min
Aug 29, 2025Episode 518
Celebrating Django's 20th Birthday With Its Creators

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1 hr 17 min
Aug 22, 2025Episode 517
Agentic Al Programming with Python

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1 hr 5 min
Aug 19, 2025Episode 516
Accelerating Python Data Science at NVIDIA

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1 hr 10 min
Aug 11, 2025Episode 515
Durable Python Execution with Temporal

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1 hr 13 min
Jul 18, 2025Episode 514
Python Language Summit 2025

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1 hr 8 min
Jul 14, 2025Episode 513
Stories from Python History

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1 hr 8 min
Jul 2, 2025Episode 512
Building a JIT Compiler for CPython

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54 min
Jun 25, 2025Episode 511
From Notebooks to Production Data Science Systems

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1 hr 2 min
Jun 18, 2025Episode 510
10 Polars Tools and Techniques To Level Up Your Data Science

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57 min
Jun 11, 2025Episode 509
GPU Programming in Pure Python

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1 hr 11 min
Jun 6, 2025Episode 508
Program Your Own Computer with Python

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1 hr 3 min
Jun 2, 2025Episode 507
Agentic AI Workflows with LangGraph

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1 hr 4 min
May 19, 2025Episode 506
ty: Astral's New Type Checker (Formerly Red-Knot)

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