Journal Review in Transplant Surgery: History and Challenges of Xenotransplantation

*** FELLOWSHIP APPLICATION: https://docs.google.com/forms/d/e/1FAIpQLScxkGQTz-rh5OfPJBBdyvVZ4Pq2R8NWgBUOC1dt8VQHtvawhw/viewform *** Inspired by recent transplant surgery headlines, in this episode we briefly review the history and challenges of xenotransplantation. We discuss an article recently published in the American Journal of Transplantation describing the transplant of a porcine kidney into a human decedent model. Learning Objectives · Understand the timeline of xenotransplantation and its historical challenges · Review a recent article that describes the transplantation of a genetically-modified porcine kidney into a brain-dead human model · Discuss ongoing obstacles to successful xenotransplantation and next steps References Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld-Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., Stegner, K. L., Dandro, A., Kokkinaki, M., Kuravi, K. v., Reed, R. D., Fatima, H., Killian, J. T., Baker, G., Perry, J., … Locke, J. E. (2022). First clinical-grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation , 22 (4). https://doi.org/10.1111/ajt.16930 Schlich, T., & Lutters, B. (2022). Historical perspectives on xenotransplantation. The Lancet , 399 (10331). https://doi.org/10.1016/s0140-6736(22)00529-3 Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.