October 28, 2025
MCAS, Histamine, and POTS: The Latest Research and Root Causes with Michelle Shapiro, RD
Well-Fed WomenAbout this episode
Michelle Shapiro is back to uncover the shocking truths about MCAS, histamine intolerance, and POTS that most people, including practitioner, get wrong. We dive into the latest science, why “detoxing” or chasing root causes too soon can actually backfire, and how to begin the path to healing. If you’ve ever felt dismissed, confused, or stuck in your symptoms, this conversation will change how you see chronic illness. Timestamps: [1:36] Welcome [5:20] Interview with Michelle Shapiro [6:11] How often do histamine or mast cell issues show up under the surface when people don’t realize it? [11:14] Is there anything that you need to clear or calm down the activation? [14:18] What are the earliest red flags that someone's unexplained symptoms could be mast cells or a histamine reaction? [18:02] Are there different symptoms with MCAS verses histamine issues or do they always coincide? [21:12] What are some common root cause of histamine issues? [28:44] How is someone targeting their nervous system and histamines? [39:01] What is it about cycle changes that make you react more to high histamine foods? [43:10] What do you recommend people do to figure out their root cause? Are there specific tests or timelines? [49:04] If someone’s in the middle of a reaction, what do you recommend they do in the short to to immediately reduce the symptoms? [53:40] How do you know when it’s time to come off of medications that are working well? [56:12] Do you feel like you ever truly heal mast cells and histamine or is it something you just manage? [1:05:23] I break out in hives while exercising. How do I manage this so I can get movement in? [1:07:24] Histamine issues - I get pain in my feet after I nursed my third child - why? [1:08:31] I’m down to three safe foods - how can I improve tolerance to food? Episode Links: Visit Michelle's Website Michelle's Histamine Webinar Quiet the Diet Podcast Follow Michelle on Instagram Episode #534: Weight Loss and Diet Changes without Diet Culture with Michelle Shapiro, RD. Sponsors: Go to https://thisisneeded.com/ and use coupon code WELLFED for 20% off your first order. Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order. Go to http://mdlogichealth.com/chocolate and use coupon code COLLAGEN15 for 15% off. Go to wellminerals.us/creatine and use code WELLFED to get 10% off your order.