October 22, 2025
How Exercise Can Transform Mental Health and Depression with Dr. Nicholas Fabiano
Well Beyond 40About this episode
What if the most powerful antidepressant isn’t in a pill, but in your sneakers? In this episode, I speak with Dr. Nicholas Fabiano about the science behind why movement can be as effective as antidepressants. We also explore the social and psychological benefits of staying active and how even small steps can spark powerful change. You’ll also hear fascinating insights about creatine, brain energy, and how lifestyle prescriptions may soon reshape the future of psychiatry. Dr. Nicholas Fabiano is a psychiatry resident and researcher at the University of Ottawa with a passion for the mind-body connection. Originally from Thunder Bay, he turned a broken arm from an arm-wrestling match into a fascination with how exercise, nutrition, and sleep can transform mental health. Today, his work in lifestyle psychiatry explores how simple daily habits can powerfully impact depression and overall well-being. What you’ll learn: (02:57) How Dr. Fabiano’s own injury sparked his passion for exercise and mental health. (05:42) Why exercise benefits the brain beyond mood. (07:48) The real science behind exercise and depression, including serotonin, inflammation, and brain growth factors. (09:11) How the social and psychological aspects of movement can be just as healing as the biological ones. (11:40) Simple, practical ways to motivate someone struggling with depression to get moving again. (14:17) Why the best type of exercise is the one you’ll actually do—and how adherence matters more than modality. (18:45) How Dr. Fabiano “prescribes” exercise using the FITT framework (Frequency, Intensity, Time, Type). (29:25) The surprising connection between creatine supplementation, brain energy, and depression recovery. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/happyworkout Learn more about your ad choices. Visit megaphone.fm/adchoices