SNR #167: Dom D'agostino, PhD - Traumatic Brain Injury, CTE & Implications for Combat Sport Athletes

Episode 167: Dominic D'Agostino, PhD returns to the show to discuss issues related to traumatic brain injury (including CTE) and associations with contact sports such as boxing, MMA and American football. Dominic D'Agostino, Ph.D. Dr. D'agostino is an Assistant Professor at the College Of Medicine Molecular Pharmacology & Physiology at the University of South Florida. The primary focus of his laboratory is developing and testing metabolic-based therapies, including ketogenic diets, ketone esters, ketone supplements and metabolic-based drugs. His research also explores the use of these metabolic therapies for a broad range of disorders linked pathophysiologically to metabolic dysregulation, including seizures, neurological disorders, wound healing, muscle wasting and cancer. The laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies. In This Episode We Discuss: Development of chronic TBI Chronic traumatic encephalopathy (CTE) and association with combat sports and American football Potential risk reduction strategies for combat sport athletes What's going on in the brain after injury? - GABA, glutamate, elctrolytes, etc. Substrate metabolism in the brain and neuro-inflammatory response after injury