NFL Week 1 DraftKings Picks 2025 | Best DFS Lineups, Ownership & Pick’em Plays

NFL is back! In this video, Pat Mayo , Tyler Tamboline and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 1 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 1. Whether you’re entering GPPs or cash games, this guide has you covered. FREE WEEK + 25% OFF NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayo $500K NFL Survivor ($50 Per Entry): https://bit.ly/mayo-survivor Use code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $50 in your account Get a Deposit BONUS Coolbet: https://shorturl.at/CHfyW Subscribe, Rate and Review Apple: http://bit.ly/PMEiTunes Spotify: https://goo.gl/VboemH #UDPartner JOHNNIE WALKER — To claim a c ustomized Blue Label Sunday Golf Bag by Devereux Go to johnniewalker.com/blue-in-water BETTERHELP — Visit BetterHelp.com/PATMAYO today to get 10% off your first month. CHUBBIES — Your new wardrobe awaits! Get $10 off @chubbies with the code MAYO at https://www.chubbiesshorts.com/MAYO #chubbiespod FOLLOW MAYO MEDIA NETWORK Newsletter: https://mayomedia.substack.com/ Instagram: https://www.instagram.com/mayomedianetwork/ TIK TOK: https://www.tiktok.com/discover/mayo-media-network YOUTUBE: https://bit.ly/YTMMN Show Index 00:00 Intro 00:41 TNF Takeaways 16:51 Week 1 DK Main Slate Overview 19:27 Optimal + CLE/CIN 42:11 MIA/IND 54:05 DEN Stack 59:51 WAS/NYG 1:07:46 ARZ/NO Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org ; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.