NFL Week 16 DraftKings Picks 2025 | Best DFS NFL Lineups, Ownership Projections

Pat Mayo , Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 16 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 16. Whether you’re entering GPPs or cash games, this guide has you covered. code "MAYO50" FREE WEEK + 50% OFF MONTHLY NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayo $1.2M Race for the Mayo Cup Fantasy League: https://fantasygolfchampionships.shgn.com/ Use code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $75 in your account Get a Deposit BONUS Coolbet: https://shorturl.at/CHfyW Subscribe, Rate and Review Apple: http://bit.ly/PMEiTunes Spotify: https://goo.gl/VboemH OMAHA STEAKS — Make game day delicious with the Official Sponsor of Tailgating®. Visit OmahaSteaks.com and get $35 OFF with Promo Code MAYO at checkout. BETTERHELP -- Our listeners get 10% off at BetterHelp.com/PATMAYO . FOLLOW MAYO MEDIA NETWORK Newsletter: https://mayomedia.substack.com/ Instagram: https://www.instagram.com/mayomedianetwork/ TIK TOK: https://www.tiktok.com/discover/mayo-media-network YOUTUBE: https://bit.ly/YTMMN #UDPartner #NFL #NFLDFS #DraftKings #DFSLineups #NFLPicks #NFLWeek12 #DFSFootball #DailyFantasy #NFLDFS2025 #FantasyFootball #NFLPredictions #BestBets #DFSOwnership #DraftKingsPicks #NFLDraftKings #NFLLineups #DFSWeek12 #NFLFantasy #FantasyFootball2025 #NFLOwnership Show Index 00:00 Intro 2:30 SLATE OVER OVERVIEW 4:01 OPTIMAL + ARZ/ATL 27:49 DET/PIT 34:07 NYJ/NO 46:11 MIN/NYG 50:29 HOU 57:02 DAL/LAC 1:01:09 MIA/CIN Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.