Estrogen Cream for the Face: What the Science Says About Anti-Aging, Collagen, and Hormones

Is estrogen cream for the face really the new holy grail of anti-aging—or is it another skincare trend overselling its promise? In this episode of The Dr. Brighten Show , Dr. Jolene Brighten breaks down the biology behind estrogen and skin aging, why women’s skin often changes rapidly after 35, and what clinical studies actually show about using topical estrogen on the face. This isn’t about chasing youth—it’s about understanding collagen loss, inflammation, and how hormonal shifts during perimenopause and menopause directly affect the skin. What You’ll Learn in This Episode In this episode, you’ll learn how estrogen interacts with the skin at a cellular level, why traditional skincare often stops working in midlife, and how clinicians are using estrogen cream for the face —specifically estriol and estradiol—in a thoughtful, medically supervised way. Dr. Brighten explains who may benefit, how these creams are typically used, what results are realistic, and which healthcare providers are qualified to prescribe them, all through a women’s-health-first, evidence-based lens. This Episode Is Brought to You By Dr. Brighten Essentials Radiant Mind —a science-backed formula created to support women’s brain health through every stage of life. If you’ve ever felt the brain fog of perimenopause or noticed how ADHD can amplify challenges with focus, memory, mood, or sleep, you’re not alone. Radiant Mind combines clinically studied saffron extract, Bacognize® Bacopa, Cognizin® Citicoline, and zinc to help nourish your brain chemistry and support clarity, calm, and resilience. Shop now https://drbrighten.com/radiant/ OneSkin Founded by an all-woman team of PhD-level scientists, OneSkin is revolutionizing aging with the OS-01™ peptide, the first ingredient proven to reverse skin’s biological age by targeting cellular senescence. The result? Skin that looks, feels, and acts younger. It’s never too early — or too late — to invest in your skin health. Shop now https://oneskin.pxf.io/c/1950532/2885132/31050 LUMEBOX Ready to take your skincare results to the next level—right from home? 💡 LUME Box delivers professional-grade LED light therapy in a sleek, easy-to-use device that targets fine lines, pigmentation, and dullness at the cellular level. Just minutes a day can help boost collagen, calm inflammation, and reveal that lit-from-within glow. It’s the same science trusted in top dermatology clinics, now in your hands. Shop now → https://drbrighten.com/lumebox use code drbrighten for our exclusive community discount on your purchase. 👩🏻‍⚕️ Follow Dr. Jolene Brighten: 💻 Website: ⁠⁠ https://www.drbrighten.com ⁠⁠ 📸 Instagram: ⁠⁠⁠ ⁠https://www.instagram.com/drjolenebrighten⁠ 🎥 TikTok: ⁠⁠ https://www.tiktok.com/@drjolenebrighten ⁠⁠ 🧵Threads: ⁠⁠ https://www.threads.net/@drjolenebrighten ⁠⁠ 🌟 Grab my free hormone friendly recipes here! ⁠⁠ https://drbrighten.com/hormonekit/ ⁠⁠ 🎧 Subscribe to the Podcast: Apple: ⁠⁠ https://podcasts.apple.com/us/podcast/the-dr-brighten-show/id1786362161 ⁠⁠ Spotify: ⁠⁠ https://open.spotify.com/show/5VWcYWJFzi3OnwidT25IXi?si=481df20ef0a6417 ⁠⁠ YouTube:⁠ ⁠ https://www.youtube.com/@drjolenebrighten ⁠⁠⁠ 👉 If you found this episode valuable, drop a comment below to tell us what you loved most, and share it with a friend! Let’s spread the knowledge. 💬✨ Learn more about your ad choices. Visit megaphone.fm/adchoices