July 29, 2025
81. Dr. Zain Kassam: How Your Gut Bacteria Control Your Brain, Weight, and Longevity
Extend Podcast with Darshan Shah, MDAbout this episode
What if I told you there's an organ in your body with more cells than the Milky Way has stars—and most doctors barely think about it? In this episode of Extend, I sit down with Dr. Zain Kassam, a gastroenterologist turned microbiome researcher who's pioneering how we understand the trillions of organisms living in and on us. We dive into why your gut bacteria aren't just bystanders—they're actively producing molecules that affect your mood, metabolism, immune system, and even longevity. We also explore the gut-brain connection, why not all probiotics are created equal, and how the microbiome influences everything from depression to skin health. Dr. Zain Kassam is a gastroenterologist, microbiome researcher, and Chief Medical Officer at Seed Health. He trained at McMaster University, Harvard, and MIT, where he pioneered clinical applications of microbiome science. He's led groundbreaking research on fecal transplants and develops evidence-based probiotic therapies. We Also Discuss: The Microbiome Revolution: From Forgotten to Life-Saving Why Your Gut Has More Cells Than the Milky Way Has Stars How Gut Bacteria Control Your Brain and Mood The Butyrate Connection: Your Microbiome's Master Molecule Why Most Probiotics Are Marketing Hype (And How to Choose Better) The 4D Framework: Diversity, Delivery, Do-Gooders, and Data Microbiome Testing: Crystal Ball or Expensive Guesswork? From C. Diff to Cancer: When Gut Health Becomes Life or Death The GLP-1 Secret: How Your Gut Makes Its Own Ozempic Post-Antibiotic Recovery: Rebuilding After the Nuclear Bomb Thank You for Our Sponsors: Pendulum: Use code DARSHAN or use the link https://pendulumlife.com/discount/DARSHAN to get 20% off IM8: Try IM8 today with a 30-day money back guarantee. You can get 20% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH . Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/ Learn more about Dr. Zain Kassam: X: https://x.com/DrZainSays/ Instagram: https://www.instagram.com/seed/ Get 25% off DS-01 with code EXTEND25 at Seed.com