The Metabolic Impact of GLP-1s on Obesity | Spencer Nadolsky, DO | Ep.65

Join us for a FREE Live Q&A with Dr. Spencer Nadolsky on April 22nd at 9am PT / 12pm ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of expert-led videos on metabolic health and therapy, CME opportunities, and more here! In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Spencer Nadolsky—board-certified obesity and lipid specialist, former NCAA heavyweight wrestler, and founder of Vineyard—to explore one of the most hotly debated and often misunderstood tools in modern medicine: GLP-1 receptor agonists. Together, they take a deep dive into how these drugs work, who they’re for, and why they might not always be a magic bullet. Dr. Nadolsky shares clinical insights into the real-world use of semaglutide, tirzepatide, and combination therapies, breaking down everything from appetite regulation and side effects to muscle loss, mood changes, and the potential future of prevention. They also tackle pediatric obesity, long-term use vs. off-ramping, and the critical role of resistance training and nutrition for protecting muscle mass while on these medications. Special thanks to the sponsors of this episode: ✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here ✅ Fatty15 – Get 15% off a 90-day Starter Kit here (use code METABOLICLINK ) ✅ Zocdoc – Find and instantly book a top-rated doctor here ✅ Puori – Get 20% off supplements with code METABOLICLINK here 🧠 Learn more about Dr. Nadolsky → drspencer.com 💥 Don’t forget to RSVP for the live Q&A on April 22! 🎟️ membership.metabolicinitiative.com/drspencer In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel ! Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.