Why Some People Stay Lean Without Trying (The Genetics of Fat Loss) with Dr. Stephan Guyenet | Ep 214

Are you frustrated by the stubborn body fat that won't come off despite all your efforts? Do you ever wonder if it's all due to lack of discipline, or could there be a deeper reason? And how much do your genetics actually play a role in your fat loss journey? Philip ( @witsandweights ) dives into the fascinating world of neuroscience and body composition with special guest Dr. Stephan Guyenet, a neuroscientist, obesity researcher, and author of The Hungry Brain. They explore the science behind why some people struggle more than others to lose weight and how genetics might be the hidden force shaping your body fat levels. Dr. Guyenet also breaks down how the brain’s reward system influences your cravings and reveals how minor tweaks to your environment and habits can make a huge difference in your fat loss efforts. Dr. Stephan Guyenet has spent over a decade studying the neuroscience of obesity. With a PhD in neuroscience, his work focuses on the brain's role in regulating body fat and how our modern environment contributes to weight gain. He is also the founder of Red Pen Reviews, which provides scientific accuracy scores for popular health and nutrition books. 📱Book a FREE 15-minute Rapid Nutrition Assessment , designed to fine-tune your strategy, identify your #1 roadblock, and give you a personalized 3-step action plan in a fast-paced 15-minute call. Today, you’ll learn all about: 2:07 Genetics vs. environment: What really causes differences in body fat? 3:48 When do genetic predispositions for body fat develop? 7:56 Why we care about body fat: Individual health and misinformation 11:58 Muscle mass and body fat: How energy overload impacts health 17:24 How your brain regulates hunger and satiety 29:53 Metabolic adaptation during fat loss 32:42 The carbohydrate-insulin model of obesity debunked 44:05 Making body composition changes easier and frictionless 51:54 Insights from studying naturally lean people 54:33 Where to find Stephan 54:49 Outro Episode resources: Dr. Stephan Guyenet’s Website: stephanguyenet.org Twitter: @sguyenet Red Pen Reviews: redpenreviews.org Support the show 📱 Get Fitness Lab - Philip’s science-based AI app for fat loss, muscle building, and strength training for people over 40. It adapts to your nutrition, recovery, and training to improve body composition without guesswork. 🎓 Try Physique University - Evidence-based nutrition coaching and strength training to help you lose fat, build muscle, and master your metabolism with support and accountability (free custom nutrition plan with code FREEPLAN ). 👥 Join our Facebook community - Free fat loss, muscle building, and body recomposition strategies for adults over 40 who want practical, science-backed fitness guidance. 👋 Ask a question or find Philip Pape on Instagram