About this episode
Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta during deep sleep. Listeners learn how even a single night of deprivation can spike harmful tau levels by 50%, effectively accelerating brain aging. The discussion pivots to dual orexin receptor antagonists (DORAs), a drug class that quiets wakefulness rather than forcing sedation. Matt highlights research from Dr. Brendan Lucey and Dr. David Holtzman showing these agents may lower toxic proteins and preserve the hippocampus. Despite this therapeutic promise, he emphasizes that natural sleep remains the ultimate gold standard for neuroprotection. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. One of this week's sponsors, LMNT , offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their new limited-time Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker . Stock up on this summer flavor while it lasts! Another sponsor, Shopify , made launching Matt's merchandise incredibly smooth with its integrated sales system. Shopify simplifies everything from online stores to in-person sales. Start your exclusive trial and see for yourself at shopify.com/mattwalker . Craving more energy, better metabolism, and immunity? Discover Pique's Nandaka, a ceremonial cacao superfood blend for calm, sustained energy without the crash. Thanks to this wonderful podcast partner, you can now get 20% off for life at piquelife.com/mattwalker using code MattWalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker , X @sleepdiplomat , YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg