The Randle Cycle: How Your Body Chooses Between Glucose and Fat

In this episode of The Metabolic Classroom, Dr. Bikman introduces the concept of the Randle Cycle, also known as the glucose fatty acid cycle, in a lecture aimed at providing a better understanding of metabolism. The Randle Cycle, first identified by Dr. Philip Randle and his colleagues in the 1960s, explores how cells decide between using glucose or fatty acids for fuel. Dr. Bikman emphasized that this cycle has been misinterpreted on social media and aims to clarify its relevance in metabolic functions and nutritional decisions. https://www.insuliniq.com 00:00 - Introduction to the Metabolic Classroom and Dr. Ben Bikman 01:00 - Overview of the Randle Cycle (Glucose Fatty Acid Cycle) 02:00 - Historical Background: Philip Randle’s Research 03:00 - Experimental Model: Perfused Rat Hearts 04:00 - Key Terms: Glucose and Fatty Acids 05:00 - Concept of Substrate Competition 06:00 - Reciprocal Inhibition: Fats vs. Glucose 08:00 - Fatty Acid Oxidation Process 10:00 - Biochemical Pathways: Acetyl-CoA, NADH, and Pyruvate Dehydrogenase 12:00 - Role of Citrate in Glycolysis Inhibition 14:00 - Glucose Utilization and Malonyl-CoA 16:00 - Insulin’s Role in Fuel Selection 18:00 - Insulin’s Impact on Glucose and Fat Burning 20:00 - Diabetes Case Study: Type 1 and Type 2 22:00 - Type 1 Diabetes: High Glucose and Fatty Acids 24:00 - Ketones Production in the Liver 26:00 - Type 2 Diabetes: Insulin Resistance and Metabolic Inflexibility 28:00 - Insulin Resistance in Fat Cells 30:00 - Metabolic Inflexibility in Type 2 Diabetes 32:00 - Insulin Resistance in the Brain 34:00 - The Impact on Hunger and Neurological Disorders 36:00 - Conclusion: Importance of Insulin in Metabolic Health #Metabolism #RandleCycle #DrBenBikman #InsulinResistance #GlucoseMetabolism #FattyAcidOxidation #MetabolicHealth #DiabetesResearch #Ketosis #Type1Diabetes #Type2Diabetes #InsulinRole #CellBiology #NutritionalScience #MetabolicFlexibility #Ketones #GlucoseUtilization #FatBurning #BiomedicalScience #HealthLecture My favorite meal-replacement shake: https://gethlth.com (discount: BEN10) My favorite electrolytes (and more): https://redmond.life (discount: BEN15) My favorite allulose source: https://rxsugar.com (discount: BEN20) References: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/randle-cycle Insulin Regulation of Ketone Body Metabolism: https://onlinelibrary.wiley.com/doi/10.1002/0470862092.d0308 The Effects of a Ketogenic Diet and Exercise Interventions on Cognitive Function: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.31.1_supplement.lb810 (Due to character length constraints, not every reference is posted above. For a complete list, please email: support@insuliniq.com with your request.) Hosted on Acast. See acast.com/privacy for more information.