280. CCC: Sedation in the Cardiac ICU with Dr. Christopher Domenico

The practice of critical care cardiology relies on the use of invasive hemodynamics, mechanical ventilation, mechanical circulatory support, and other advanced techniques to help our patients recover from critical cardiac illnesses. To facilitate these interventions, it is essential to have a broad understanding of how sedation and analgesia keep our patients comfortable and safe throughout their time in the CICU. In this episode, series co-chair, Dr. Yoav Karpenshif, and CardioNerds co-founder, Dr. Daniel Ambinder, are joined by Dr. Natalie Tapaskar, cardiology fellow and CardioNerds FIT Ambassador from Stanford, and faculty expert, Dr. Chris Domenico, to discuss sedation in the cardiac ICU. Notes were drafted by Dr. Natalie Tapaskar. Audio editing by CardioNerds academy intern, Anusha Gandhi. We discuss the use of analgesics and sedative medications in the cardiac ICU. We dissect three cases of VT storm, heart failure associated cardiogenic shock, and cardiac arrest. We assess the hemodynamic, arrhythmic, and metabolic effects of opioids and sedatives and delve into the altered pharmacokinetics of these drugs during targeted temperature management. Most importantly, we highlight the use of structured pain and sedation scoring systems and discuss the recognition and management of ICU delirium both from a pharmacologic and non-pharmacologic standpoint. The CardioNerds Cardiac Critical Care Series is a multi-institutional collaboration made possible by contributions of stellar fellow leads and expert faculty from several programs, led by series co-chairs, Dr. Mark Belkin, Dr. Eunice Dugan, Dr. Karan Desai, and Dr. Yoav Karpenshif. Pearls • Notes • References • Production Team CardioNerds Cardiac Critical Care PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Sedation in the Cardiac ICU with Dr. Christopher Domenico Think about analgesia and sedation as separate entities with management of analgesia first and sedation second. Frequent re-assessment of needs should be performed to reduce ICU delirium and improve long-term outcomes. Fentanyl is generally a good starting point for analgesia in the ICU since it is fast on/fast off, but can stick around for a long time the longer it is used. The choice of bolus or continuous infusion opioids depends on the clinical scenario and personal/institutional preference. Remember to administer bolus doses that are 50-100% of the hourly continuous infusion dose to reach steady state faster. When managing refractory VT storm with sedative agents (propofol, benzodiazepines and/or dexmedetomidine), you should target the deepest level of sedation necessary to suppress sympathetic drive. For cardiogenic shock patients, the choice of sedative agent is a nuanced decision. Think about etomidate first for intubation as it has the least cardiovascular and hemodynamic impact. And remember the propofol trifecta: negative inotropy, direct vasodilation, and bradycardia! Pharmacokinetics are disrupted during targeted temperature management, thus be weary of overly sedating patients due to reduced drug clearance. Show notes - Sedation in the Cardiac ICU with Dr. Christopher Domenico How do we initiate analgesics and sedatives? Analgesia first and sedation second! Analgesia: think about how to reduce a patient’s painEveryone has a different pain tolerance and critically ill patients can have moderate to severe pain at baseline. Metrics to assess pain include self-reported scales, behavioral scales, facial expressions, extremity movement, compliance with the ventilator, tachycardia, tachypnea, and hypertension. Sedation: think about how to reduce a patient’s agitation or anxietyThe target depth of sedation depends on the clinical scenario.For example, a patient with a femoral balloon pump may need more sedation if agitation is causing excessive lower extremity movement and thus a higher risk of device dislodgement. Use the Richmond Agitation and Sedation Scale (RASS) for titrating sedation leve.-5 – Unarousable. No response to voice or physical stimuli-4 – Deep sedation. No response to voice, but movement or eye opening to physical stimulation-3 – Moderate sedation. Movement or eye-opening to voice-2 – Light sedation. Briefly awakens to voice-1 – Drowsy. Not fully alert, but has sustained awakening to voice0 – Alert and calm+1 – Restless. Anxious, apprehensive, but not aggressive+2 – Agitated. Frequent non-purposeful movement, fights vent+3 – Very agitated. Pulls or removes tubes/catheters +4 – Combative. Violent, immediate danger to staff What are the different opioid options and when should we use them? Break down opioids into 3 groups (as per Dr. Domenico):Group 1 (morphine, hydromorphone, fentanyl) for pain management in the ICU.Onset of action: Fentanyl is the quickest on/off (30 seconds-2 minutes), but is highly lipophilic, redistributing in fatty tissues after ~30 minutes. The longer you use fentanyl, the longer it will stick around – i.e. “context-sensitive half-time.” Morphine and Hydromorphone have an onset from 5-15 minutes.Half-life: All 3 are similar at 2-4 hours. (Fentanyl can be even higher the longer it is used).Metabolism: Morphine is metabolized by the liver, but has active metabolites that are renally cleared; thus, be cautious with high doses in renal impairment. Fentanyl is metabolized by the CYP system thus it accumulates in hepatic dysfunction.Group 2 (remifentanil and sufentanil) generally for use in the operating room.Onset of action: Both are very quick on/off ranging from 1-3 minutes.Half-life: Remifentanil’s is 3-10 minutes, whereas sufentanil’s is 2-3 hours.Metabolism: Remifentanil demonstrates no accumulation in hepatic or renal impairment, thus is a good choice in these scenarios. Beware of the rare possibility of serotonin syndrome with both these agents. Group 3 (methadone) as a bridge to wean off from long term infusions of other opioids.Onset of action: 1-20 minutes when given intravenously, but 3-5 days when given orally.Half-life: Ranges from 8-60 hours. Metabolism: Hepatic, exercise caution with dysfunction. Also monitor for QT prolongation. Should we administer opioids as boluses or continuous infusions? There is no strong data to guide bolus versus continuous infusion dosing of opioids and the choice is often left up to personal/institutional preference. Small studies in emergency department patients suggest there is less ICU delirium post-intubation with bolus dosing over continuous infusions of opioids. Generally, think about starting with bolus dosing to assess a patient’s true needs, but patients may require continuous infusions if they are receiving frequent boluses. When increasing the rate of a continuous infusion, one can reach steady state faster by administering bolus doses at 50-100% of the hourly dose of the infusion. How should we use analgesics and sedatives for management of arrhythmias, specifically VT storm? The main goal in refractory VT storm is to sedate the patient as deeply as necessary to suppress their sympathetic drive. Generally, the choice of sedative agent is less important than the level of sedation achieved.Propofol, benzodiazepines, and dexmedetomidine can all decrease sympathetic drive.Propofol has some anti-arrhythmic effects via autonomic nervous system modulation.Dexmedetomidine may increase the arrhythmogenic threshold. Benzodiazepines have no direct effect on the conduction system. Opioids have GABA agonist properties and thus have some anti-arrhythmic properties. However, opioids alone are rarely effective in managing malignant arrhythmias unless pain is the main trigger for the arrhythmia. In some animal studies, fentanyl and morphine are thought to increase the ventricular fibrillation threshold, but this is not validated with hard outcomes in clinical trials. What sedatives are safe to use for intubation in cardiogenic shock? Induction: Etomidate, ketamine, and propofol are common agents used for induction of sedation peri-intubation.Etomidate - has minimal cardiovascular/hemodynamic effects and should be considered first for induction in cardiogenic shock. Can lead to adrenal insufficiency. Ketamine - is a direct vasoconstrictor (including coronary arteries) and results in hypertension and tachycardia. It should be avoided in patients with ACS. It may have a direct myocardial depressant effect, so its use is avoided in prolonged shock states. Propofol - has a plethora of properties-sedative, hypnotic, amnestic, antiemetic, and anticonvulsant, but importantly has NO ANALGESIC properties. Remember its hemodynamic trifecta: negative inotropy, direct vasodilation, and bradycardia. It is also highly lipophilic, with a long half-life with extended infusions- i.e. “context-sensitive half-time”. Don’t forget to check triglyceride levels at baseline and at regular intervals while on a continuous infusion. Maintenance: Propofol, benzodiazepines, and dexmedetomidine can be used for maintenance of sedation post-intubation.BenzodiazepinesAlso have a plethora of properties- sedative, amnestic, anticonvulsant, anxiolytic, and hypnotic but NO ANALGESIC properties.Midazolam is quicker on/off (2-5 minutes) compared to lorazepam. Midazolam can accumulate in renal dysfunction. Think about polyethylene toxicity when patients on lorazepam at high doses for extended periods of time develop metabolic acidosis.In general, benzodiazepines use is associated with increased ventilator time, ICU delirium, and ICU length of stay. Dexmedetomidine Is an alpha 2 agonist and thus monitor for hypotension and bradycardia with ongoing use. It does not cause respiratory depression.