010 Dr. David Sinclair – Why We Age and Why We Don't Have To

00:52 – Introducing today’s guest, David Sinclair 06:28 – David’s origin story 08:38 – Why we age 11:17 – The genome and epigenome 13:00 – The piano metaphor 15:51 – Sirtuins explained 21:59 – Other environmental stressors that sirtuins detect 25:11 – Hormesis defined 28:13 – How NAD+ and its precursors combat aging 35:11 – Dr. Stephanie brings up a specific story from Dr. David’s book 38:40 – Friedreich's Ataxia 39:27 – Benefits of resveratrol 45:11 – Horvath's Clock and measuring age accurately 47:58 – The backup copy of the epigenome 53:44 – Anti-aging technologies on the horizon 55:07 – Other anti-aging best practices 56:47 – Dr. Stephanie suggests a new sequel to the Avengers franchise 57:48 – Dr. Stephanie thanks Dr. David for joining the show 58:21 – Dr. David shares with the audience where they can find the cheat sheet in his book 58:48 – Where listeners can follow Dr. David 1:00:00 – Where listeners can follow Dr. Stephanie and subscribe to her newsletter TWEETABLE QUOTES “I wrote the book because there’s a lot of really interesting technology and things people can do in their daily lives, I believe, to live significantly longer and healthier. But, I also wanted to start the conversation because I felt no one was really saying the kinds of things that I was saying.” (08:15) “I think that the major driver of aging, put simply, is a loss of information.” (10:19) “I think it’s worth clarifying that the sirtuins are protectors of our bodies, but they can also cause aging by being distracted too much.” (25:11) “It’s all about being uncomfortable. Our bodies would much rather sit in a chair and eat popcorn. There’s a whole industry based on that.” (26:19) “I like to joke that scientists like to fight because the stakes are so low.” (42:41) “We can predict, very accurately, how old someone is biologically. And that’s not so much related to birthday candles. It’s more about how you’ve lived your life. Twenty percent of your age will be genetic and eighty percent will be how you’ve lived.” (46:59) “What I don’t know is how to bring people back from the dead, but I think we’re getting close to being able to keep people alive in a healthy way for much longer.” (57:31) LINKS MENTIONED Better! Website Dr. Stephanie’s Website Dr. Stephanie’s Twitter – @dr_stephanie Dr. Stephanie’s Instagram – @dr.stephanie.estima Dr. Stephanie on LinkedIn Dr. David’s Book - Lifespan: Why We Age―and Why We Don't Have To Dr. David’s Website Dr. David’s Instagram – @davidsinclairphd Dr. David’s Twitter – @davidasinclair Dr. David’s Facebook ADDITIONAL RESOURCES FOR THIS PODCAST In animal models, more NAD is better At least when it is paired with exercise The Mathematical Theory Of Aging The Horvath Clock Reversal Of Aging & Cellular Reprogramming Resveratrol effects 1 Resveratrol effects 2 NMN & lifespan in mice David’s Newsletter David’s book ENJOYING THE SHOW, READY FOR MORE? Please Subscribe to Better! With Dr. Stephanie Join our Private Facebook Community for Better! Rate and Review: Show your support and help spread the word by writing a review, along with a 5-star rating on Apple Podcasts: https://bettershow.co/apple 🎙️🎙️🎙️ Podcast production and marketing provided by FullCast Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.