#017 - David Sinclair: Curing Aging, Longevity, Genes, Epigenetics, Red Wine And Resveratrol, NAD, The Methylation Clock, Fasting, Biological Vs. Ment...

Full Shownotes And Transcript: MelanieAvalon.com/lifespan Stuff I Like: MelanieAvalon.com/StuffILike 14:40 - David's Quest For Longevity 17:15 - Do Yeast And Rodent Trials Apply To Humans? 19:05 - Historical Theories Of Aging 21:45 - The (Lost) Information Theory Of Aging 22:30 - What Do Genetics And Epigenetics Look Like On A Cellular Level? 27:25 - The Piano/Pianist Gene/Epigenome Analogy 28:45 - What Is Methylation? 30:10 - The Scratched DVD Analogy For Aging 31:05 - Removing Damage Vs. Adding Back Informatio​n 36:20 - The Genetic Methylation Clock And Yamanaka Factors 38:10 - Restoring Vision 44:35 - The Role Of Damage In Aging 49:15 - Practical Implementation Of Antiaging: Fasting, Calorie Restriction, Exercise, Cold And Heat Stress 51:50 - The Role Of Sirtuins 53:00 - Are Damaged Cells More Susceptible To Damage? 55:00 - SLEEP REMEDY: Sleep Remedy Is The Ultimate Sleep Supplement, Developed By Dr. Kirk Parlsey After Years Of Research To Naturally Restore Sleep To The Sleep-Deprived, Insomniac Navy Seals. Rather Than Knocking You Out With Drugs, Sleep Remedy Provides The Necessary Neurotransmitters And Nutrients In The Perfect Amounts To Naturally Support Your Body's Sleep Process. Use The Code MELANIEAVALON At Sleepremedy.com For 10% Off!! 59:00 - Natural Molecules That Activate Longevity Genes 59:50 - Resveratrol From Wine Vs. Supplements 1:01:50 - The Longest Lived People 1:02:30 - Biological Vs Mental Stress: The Importance Of Not Worrying 1:05:10 - IF And CR: Do You Need To Feel Hungry For Lifespan Benefits? 1:08:00 - Low Energy, Hunger, Insulin, The Mitochodria, And Longevity 1:09:30 - The Role Of Metabolism And Thyroid 1:12:00 - Ketones And Longevity The Melanie Avalon Podcast Episode #4 - Paul Saladino, MD 1:13:30 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold- Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link DryFarmWines.com/Melanieavalon To Get A Bottle For A Penny! 1:15:20 - NAD For Longevity, And NMN Supplementation 1:22:10 - Fasting And Stem Cells 1:23:10 - A Thought Experiment: Living In A 200 Year Old Society