74. Is it saturated fat or polyunsaturated fat that’s killing you? With Peter Dobromylskyj from Hyperlipid.

Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop. Time Stamps: 0:08:42 Podcast Begins 0:09:52 Peter's Background 0:16:36 The Electron Transport Chain 0:45:30 Insulin resistance is a cellular antioxidant defense mechanism https://www.pnas.org/content/106/42/17787 0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates 0:49:50 We need insulin resistance 0:54:53 All about a1a 1:00:37 How PUFAs affect mitochondria 1:02:40 PUFAs and cellular lipid accumulation 1:05:34 Pathological insulin sensitivity 1:07:52 Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4 https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub 1:12:34 The center of metabolic health: the adipocytes 1:14:08 PUFAs and tumor growth 1:15:52 Eating the perfect ratio of fatty acids 1:20:18 Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets https://academic.oup.com/jcem/article/89/4/1641/2844241 1:20:18 How PUFAs break your metabolism 1:23:20 Premature Atherosclerosis Associated With Monogenic Insulin Resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 1:25:21 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:30:16 Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/