480 | Dr. Jeff Graham | Neurodegenerative Disease & Metabolic Dysfunction: Healthspan Series, Part 3

Description: In the third and final episode of the healthspan series, Dr. Erin Faules and Dr. Jeff Graham explore the intersection between neurodegenerative disease and metabolic dysfunction—two often-connected drivers of decline. They discuss early detection strategies, the role of genetics, and insulin resistance, and emerging clinical tools to assess and reduce long-term risk. Key Topics Covered: Distinguishing normal aging from neurodegenerative disease Early signs of cognitive decline and how to detect them The role of APOE-4 and other genes in Alzheimer's risk Metabolic dysfunction as a driver of brain aging ("Type 3 diabetes") Blood-based biomarkers: phospho-tau, NFL, CRP, fasting insulin, and more Lifestyle interventions: sleep, strength training, CGMs, circadian-aligned eating Tools like CNS Vital Signs, PET scans, and neuroquant MRIs Supplements and prescriptions: Omega-3s, creatine, berberine, GLP-1s, inositol Connecting muscle mass to glucose control and long-term healthspan