December 15, 2025
Why You Can't Diet Forever: Study Results From 10,000 People Who Kept the Weight Off
Optimal Protein Podcast with Vanessa SpinaAbout this episode
Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa Why do so many people lose weight — only to regain it later? In this episode of The Optimal Protein Podcast, Vanessa Spina sits down with Dr. Holly Wyatt, physician, endocrinologist, and longtime researcher with the National Weight Control Registry (NWCR) — the world's largest and longest-running study of people who have lost weight and kept it off. Building on the audience-favorite episode with Dr. James Hill, this conversation focuses on what the data from over 10,000 successful maintainers actually shows — and why staying in fat-loss mode forever is one of the biggest reasons diets fail. OneSkin is powered by the breakthrough peptide OS-01, the first ingredient proven to reduce skin's biological age. I use the OS-01 Face and Eye formulas daily—they've transformed my skin's smoothness, firmness, and glow. Visit oneskin.co/VANESSA and use code VANESSA for 15% off your first purchase. In This Episode, You'll Learn: • Why losing weight and keeping it off require completely different skills • The exact reason staying in fat-loss mode too long backfires • What 10,000 successful maintainers had in common • The identity shift that makes maintenance stick • How environment beats willpower every time NEW! Free High-Protein Keto Guide Get delicious high protein meal recipes! Connect with Vanessa on Instagram @ketogenicgirl Get 25% off Tone LUX Crystal Red Light Therapy collection including the Crystal Mask and accessories the at https://ketogenicgirl.com with the code HOLIDAY25 HERE Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.