February 14, 2025
Study Reveals NEW Hormone LEAP2 Behind How High Protein Diets Generate Ketones & Appetite Supression
Optimal Protein Podcast with Vanessa SpinaAbout this episode
Use the code KETOGIRL for 20% off your order of Spirulina Here In today's episode of The Optimal Protein Podcast, we uncover a groundbreaking discovery about LEAP2, a newly identified hormone that plays a key role in hunger regulation, ketone production, and appetite suppression. We are breaking down a 2022 study published in Endocrinology titled b-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2 ( PubMed link ). This research reveals how ketones specifically b-hydroxybutyrate (BHB) interact with LEAP2 and the hunger hormone ghrelin, explaining why high-protein, low-carb, and ketogenic diets naturally reduce appetite and support fat loss. If you've ever wondered why a high-protein diet helps you stay full longer while promoting fat-burning, this episode explains the new science behind it! Key Takeaways -What is LEAP2? The newly discovered hormone that regulates hunger and ketone metabolism. -How high-protein diets generate ketones, even without high fat intake. -The role of BHB in appetite suppression. -How LEAP2 interacts with ghrelin, the hunger hormone. -Why hunger may temporarily increase when starting ketosis but decrease over time. -How this research explains the long-term appetite-suppressing effects of ketogenic and high-protein diets. Get 20% off the New 2nd Generation Tone Device HERE with the code VANESSA Visit Energybits.com (Use code KETOGIRL for 20% off your order) Follow @ketogenicgirl for updates on the latest studies and strategies to optimize protein intake and metabolic health. Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.