The Flower That Fights Disease: Gardenia's Hidden Power

Story at-a-glance Genipin, derived from gardenia plants, restores nerve development, and reduces neurodegeneration in patients with familial dysautonomia, a rare genetic disorder that affects the peripheral nervous system Originally discovered as a blue dye source in the 1980s, genipin has evolved from a food science application to a therapeutic compound with several medical applications Genipin works by interacting with the extracellular matrix and reorganizing cellular structure, promoting nerve repair and axon regeneration in both the peripheral and central nervous systems Studies show genipin protects against diabetic retinopathy by controlling advanced glycation end products (AGEs) and reducing oxidative stress, which helps prevent vision loss in diabetic patients In neuroblastoma research, genipin demonstrates significant anticancer properties by triggering cell death and effectively suppressing tumor growth without toxic side effects