Can Alzheimer’s Be Prevented? The Role of Genetics, Hormones & Lifestyle Choices in Cognitive Health

In this conversation with Dr. Heather Sandison, we explore what I consider to be one of medicine's most significant misunderstandings—that Alzheimer's disease, particularly in women, is an unstoppable fate. We examine the evidence behind cognitive decline, hormones, lifestyle interventions, and a framework for preventing and even reversing what was once considered irreversible. If you're interested in making evidence-based decisions about your brain health, understanding why traditional approaches have failed, or learning about the powerful role of lifestyle interventions in cognitive function, this episode provides both the scientific rationale and actionable strategies you need. Subscribe to The Neuroscience Experience for more conversations that challenge conventional thinking about brain health. I'm committed to bringing you insights that transform how we approach cognitive aging and performance. Sponsors A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/ Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions. - Get 10% off: https://troscriptions.com/NEURO - https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail Episode Timestamps: 00:00 Why Are Women More Vulnerable to Alzheimer’s? 06:13 The Role of Hormone Replacement Therapy 11:24 Understanding Alzheimer’s Disease and Dementia 17:04 Alzheimer's Drugs vs. Lifestyle Interventions That Work 29:50 APOE Gene, Genetic Risk, Lipids, and Cholesterol in Alzheimer’s 37:47 How the Ketogenic Diet Impacts Brain Health 41:11 GLP-1 Agonists and Their Role in Cognitive Health 44:30 How Infections Contribute to Cognitive Decline 48:00 Plasma Exchange and Alternative Therapies 52:09 Foundational Health Practices & Dual Task Exercise 54:17 Conclusion and Further Resources The Neuro Athletics Newsletter Instagram : @louisanicola_ Twitter : @louisanicola_ YouTube : @Louisa Nicola The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman Learn more about your ad choices. Visit megaphone.fm/adchoices