How to Safely Take Nicotinamide Riboside for Anti-Aging | Chris Masterjohn Lite #132

Nicotinamide riboside (NR) is the best form of niacin to take for anti-aging benefits. BUT… it could sap your creatine supply, making you weaker, hurting your digestion, or causing you to get depressed. AND it could mess with your dopamine, giving you "sticky brain" syndrome, causing negative thoughts and emotions to get stuck in your mind. How do we protect against this? It all comes down to dose, frequency, timing it with meals, and making sure you have enough methyl donors. Tune in for the details. This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and brain... all in the convenience of a capsule. For more information or to buy any of their products, go to https://AncestralSupplements.com This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass . Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here's a massive 2-part podcast series I did on niacin with Alex Leaf, which has 52 scientific references: Part 1: https://chrismasterjohnphd.com/2019/03/01/niacin-part-1-need/ Part 2: https://chrismasterjohnphd.com/2019/03/16/niacin-part-2-blood-tests-foods-supplements/ I don't have an affiliate relationship with Niagen, but I have one with Amazon, and if you would like to purchase the recommended product in a way that offers me a small commission to support the free work I put out at no extra cost to you, you can use this link: https://chrismasterjohnphd.com/amazon/niagen Here's a Twitter exchange I had with Charles Brenner, who patented and distributes that product, in which he ignored all my points about creatine: https://twitter.com/ChrisMasterjohn/status/1102389284798107651 https://twitter.com/CharlesMBrenner/status/1102394681550360578 The studies Brenner conducted showing NR causes massive excretion of methyl groups: https://academic.oup.com/ajcn/article-abstract/108/2/343/5051210 https://www.ncbi.nlm.nih.gov/m/pubmed/27721479/ My original video, Why You Should Be Careful With Niacin and Nicotinamide Riboside: https://chrismasterjohnphd.com/2018/07/26/careful-niacin-nicotinamide-riboside/ Start Here for MTHFR and Methylation: https://chrismasterjohnphd.com/methylation The recent videos on niacin and NAD: https://chrismasterjohnphd.com/2019/04/18/should-you-inject-yourself-with-nad/ https://chrismasterjohnphd.com/2019/04/23/best-form-niacin-anti-aging/ Access the show notes, transcript, and comments here . Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .